Infant colic: The effect of serotonin and melatonin circadian rhythms on the intestinal smooth muscle
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Cited by (32)
Maternal vitamin B-12 and folate status during pregnancy and excessive infant crying
2011, Early Human DevelopmentCitation Excerpt :It is suggested that during the first 3 postnatal months, infants may suffer more from intestinal cramps by high serotonin and low melatonin concentrations [32,33]. Because it is also during these months that excessive infant crying mostly occurs, it is hypothesized that this crying behavior is a symptom of an immature melatonin circadian rhythm [8,23,32]. Vitamin B-12, in turn, is involved in the melatonin secretion system.
Circadian genes: Mystery underlying the physiopathology of infantile colic
2009, Medical HypothesesInfluence of exogenous melatonin administration on Salmonella Enteritidis colonization in molted layers
2008, Poultry ScienceCitation Excerpt :The protective effects of melatonin in the gut are well documented. Gastrointestinal melatonin has been suggested as playing a protective role in disorders such as irritable bowel syndrome, gastroesophageal reflux disease, and intestinal colic in newborns (Talley, 1992; Weissbluth and Weissbluth, 1992). Others have reported relationships between melatonin and the digestive enzymes gastrin (Lewinski et al., 1991), cholecystokinin (Benouali et al., 1993; Jaworek et al., 2004), and pancreatic enzyme (Jaworek et al., 2004).
"The Gripe": An Integrative Approach to Infant Colic
2007, Explore: The Journal of Science and HealingCitation Excerpt :Furthermore, melatonin receptors are abundant throughout the gastrointestinal tract, and many biological effects of melatonin are produced through activation of these receptors. It has been hypothesized that because endogenous melatonin production does not mature until infants are 12 weeks old, when colic generally resolves, that abnormal circadian melatonin rhythms may be implicated in colic development.32 Why some infants are excessively irritable may have to do with differences in melatonin or receptor physiology, and perhaps administration of exogenous melatonin would be an effective colic treatment.
Sleep and Colic
2005, Principles and Practice of Pediatric Sleep MedicineSudden infant death syndrome: A genetically determined impaired maturation of the photoneuroendocrine system. A unifying hypothesis
1994, Journal of Theoretical Biology