Crick and Mitchison's theory of REM sleep and neural networks

doi:10.1016/0306-9877(93)90212-9

Medical Hypotheses

Volume 40, Issue 6, June 1993, Pages 329-331

https://doi.org/10.1016/0306-9877(93)90212-9 Get rights and content

Abstract

Crick and Mitchison proposed that a reverse learning mechanism in REM sleep removes certain undesirable modes of interaction in neural networks within the cerebral cortex. If their theory is correct then abnormalities of reverse learning might account for some aspects of schizophrenia, mania, and depression. The theory of reverse learning might lead to an understanding of why lithium salts terminate manic episodes.

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There are more references available in the full text version of this article.

Cited by (3)

The consolidation of learning during sleep: Comparing the pseudorehearsal and unlearning accounts
1999, Neural Networks
We suggest that any brain-like (artificial neural network based) learning system will need a sleep-like mechanism for consolidating newly learned information if it wishes to cope with the sequential/ongoing learning of significantly new information. We summarise and explore two possible candidates for a computational account of this consolidation process in Hopfield type networks. The “pseudorehearsal” method is based on the relearning of randomly selected attractors in the network as the new information is added from some second system. This process is supposed to reinforce old information within the network and protect it from the disruption caused by learning new inputs. The “unlearning” method is based on the unlearning of randomly selected attractors in the network after new information has already been learned. This process is supposed to locate and remove the unwanted associations between information that obscure the learned inputs. We suggest that as a computational model of sleep consolidation, the pseudorehearsal approach is better supported by the psychological, evolutionary, and neurophysiological data (in particular accounting for the role of the hippocampus in consolidation).
Autism, Asperger's syndrome and the Crick-Mitchison theory of the biological function of REM sleep
1996, Medical Hypotheses
Autism, Asperger's syndrome and other autistic syndromes are developmental brain disorders that cause serious impairments in communication, social interaction, empathy, mood and play. In addition to such deficits, the autistic syndromes involve pathologically high levels of repetitive, stereotypic, ritualistic, compulsive or obsessive behavior, together with extreme resistance to change.
According to the Crick-Mitchison theory of the biological function of rapid eye movement sleep, normal brain development in the fetus and infant depends on undisrupted function of a ‘reverse learning’ mechanism during rapid eye movement sleep. Could abnormalities in this hypothetical reverse learning during rapid eye movement sleep in the fetus explain some aspects of the autistic syndromes?
Does the Crick-Mitchison theory suggest if a drug could interfere with rapid eye movement sleep and cross the placental barrier, then that drug might cause developmental brain disorders in the fetus? Should all pregnant women completely avoid caffeine or any agent that might disrupt serotonergic or cholinergic systems?
Felonious sex crime: The possibility of unilateral cerebral irradiation for the offenders
1995, Medical Hypotheses
Some felonious sex crimes might result from compulsions that the perpetrator finds impossible to control. Under judicial systems derived from British law, the court should be extraordinarily careful in mandating any medical procedure. However, if a rapist or child molester voluntarily asks a physician for help, then medical ethics might allow destruction of part of the patient's brain for the purpose of controlling compulsive behaviour. The part of the human brain primarily associated with volition might be near the anterior cingulate sulcus. Could unilateral irradiation of an area near the anterior cingulate sulcus partially destroy the patient's volition? By leaving intact the patient's will based on language and by partially destroying the patient's will based on intuition, could the physician diminish the patient's will to commit felonious sex crimes? Would some patients reject chemical castration but accept unilateral irradiation of an area near the anterior cingulate sulcus?

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Crick and Mitchison's theory of REM sleep and neural networks

Abstract

The function of dream sleep

Nature

The recent excitement about neural networks

Nature

REM sleep and neural nets

J Mind Behav