Medical Hypotheses
Volume 55, Issue 5 , Pages 440-444, November 2000

Body temperature as a risk factor for Alzheimer’s disease

  • A. Holtzman

      Affiliations

    • Elwyn Inc.; formerly of Delaware Alzheimer’s Society, Delaware, USA
    • ,
  • E.W. Simon

      Affiliations

    • Elwyn Inc. Elwyn, Pennsylvania, USA

Received 7 June 1999; accepted 29 November 1999.

Abstract 

A number of risk factors underlie the development of Alzheimer’s disease. We propose low body temperature is also implicated. This is based on the belief that low temperature influences the biomechanics of the disease and promotes its development. Support for this hypothesis is found in a consideration of temperature effects on the disease process, in anecdotal observations and from our studies of people with Down syndrome.

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PII: S0306-9877(00)91085-5

doi:10.1054/mehy.2000.1085

Medical Hypotheses
Volume 55, Issue 5 , Pages 440-444, November 2000

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