Medical Hypotheses
Volume 55, Issue 6 , Pages 461-469 , December 2000

Natural vitamins may be superior to synthetic ones

Received 13 July 1999 ,Accepted 16 November 1999.

References 

    REFERENCES
  1. Barrett S, Herbert V. Fads, frauds, and quackery. Modern Nutrition in Health and Disease, 9th ed. Baltimore: William & Wilkins; 1999; p. 1793–1800
  2. Barrett, S. Herbert, V. The Vitamin Pushers: How the ‘Health Food’ Industry is Selling America a Bill of Goods. Amherst (NY), Prometheus Press, 1994
  3. Whitney EN, Rolfes S. Understanding Nutrition, 7th ed.. St Paul West Publishing,; 1996;
  4. Whitney EN, Hamilton EMN. Understanding Nutrition, 4th ed. New York: West Publishing,; 1987;
  5. Herbert V, Das KC. Folic acid and vitamin B12. Modern Nutrition in Health and Disease, 8th ed. Philadelphia: Lea & Febiger; 1994; p. 402–425
  6. Ensminger, A. H. Ensminger, M. E. Konlade, J. E. Robson, J. R. K. Food & Nutrition Encyclopedia, 2nd ed. New York, CRC Press, 1993
  7. The United States Pharmacopeial Convention, USAN and USP Dictionary of Drug Names. Easton (PA), Mack Printing, 1986
  8. Olson, J. A. Vitamin A, retinoids, and carotenoids. Modern Nutrition in Health and Disease, 8th ed. Philadelphia, Lea & Febiger, 1994, 287, 307
  9. Farrell, P. A. Roberts, R. J. Vitamin E. Modern Nutrition in Health and Disease, 8th ed. Philadelphia, Lea & Febiger, 1994, 326, 358
  10. Jacob, R. A. Vitamin C. Modern Nutrition in Health and Disease, 9th ed. Baltimore, William & Wilkins, 1999, 467, 483
  11. Schumann K, Classen HG, Hages M, Prinz-Langenohl R, Pietrzik K, Biesalka HK. Bioavailability of oral vitamins, minerals, and trace minerals in perspective. Arzneimittelforschung. 1997;47:369–380
  12. Vinson, J. Bose, P. Lemoine, L. Hsiao, K. H. Bioavailability studies. Nutrient Availability: Chemical and Biological Aspects. Cambridge (UK), Royal Society of Chemistry, 1989, 125, 127
  13. Vinson, J. Human supplementation with different forms of vitamin C. University of Scranton, Scranton (PA)
  14. Vinson JA, Bose P. Comparative bioavailability of humans to ascorbic acid alone or in a citrus extract. Am J Clin Nutr. 1988;48:406–601
  15. Vinson JA, Hu S, Jung S. A citrus extract plus ascorbic acid decreases lipids, lipid peroxides, lipoprotein oxidative susceptibility, and atherosclerosis in hypercholesterolemic hamsters. J Agric Food Chem. 1998;46:1453–1469
  16. Acuff RV, Dunworth RG, Webb LW, Lane JR. Transport of deuterium-labeled tocopherols during pregnancy. Am J Clin Nutr. 1998;67:459–464
  17. Burton GW, Traber MG, Acuff RV. Human plasma and tissue alpha-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E. Am J Clin Nutr. 1998;67:669–684
  18. Ross, A. C. Vitamin A and retinoids. Modern Nutrition in Health and Disease, 9th ed. Baltimore, Williams &wilkins, 1999, 305, 327
  19. Tanphaichitr, V. Thiamin. Modern Nutrition in Health and Disease, 8th ed. Philadelphia, Lea & Febiger, 1994, 359, 365
  20. Swenseid, M. E. Jacob, R. A. Niacin. Modern Nutrition in Health and Disease, 8th ed. Philadelphia, Lea & Febiger, 1994, 376, 382
  21. Leklem, J. E. Vitamin B6. Modern Nutrition in Health and Disease, 8th ed. Philadelphia, Lea & Febiger, 1994, 383, 394
  22. Plesofsky-Vig, N. Pantothenic acid and Coenzyme A. Modern Nutrition in Health and Disease, 8th ed. Philadelphia, Lea & Febiger, 1994, 395, 401
  23. Herbert, V. Folic Acid In Modern Nutrition in Health and Disease, 9th ed. Baltimore, William & Wilkins, 1999, 433, 446
  24. Vinson J. Human supplementation with antioxidants. Med Sci Res. 1992;20:145–146
  25. Holick, M. F. Vitamin D. Modern Nutrition in Health and Disease, 8th ed. Philadelphia, Lea & Febiger, 1994, 308, 325
  26. Jenkins, D. J. A. Wolever, T. M. S. Jenkins, A. L. Diet Factors Affecting Nutrient Absorption and Metabolism. Modern Nutrition in Health and Disease, 8th ed. Philadelphia, Lea & Febiger, 1994, 583, 602
  27. Macrae, R. Robson, R. K. Sadler, M. J. Encyclopedia of Food Science and Nutrition. New York, Academic Press, 1993
  28. Turner G. Spectral Data Services. Tests conducted Feb. 1993. 1993;
  29. McCormick, D. B. Riboflavin. Modern Nutrition in Health and Disease, 8th ed. Philadelphia, Lea & Febiger, 1994, 366, 375
  30. Schelling GT, Roeder RA, Garber MJ, Pumfrey WM. Bioavailability and interaction of vitamin A and vitamin E in ruminants. J Nutr. 1995;125(6):1799S–1803S
  31. Olson, R. E. Vitamin K. Modern Nutrition in Health and Disease, 8th ed. Philadelphia, Lea & Febiger, 1994, 342, 358
  32. Kasai T, Inoue K, Komatsubara H, Tsujimura M. Synthesis and antiscorbutic activity of vitamin C analogue: L-threo-hex-2- enaro-1,4-lactone ethyl ester in the guinea pig. Int J Vitamin Nutr Res,. 1993;63(3):208–211
  33. Ishida A, Kanefusa H, Fujita H, Toraya T. Microbiological activities of nucleotide loop-modified analogues of vitamin B12. Arch Microbiol. 1994;161(4):293–299
  34. Nakano H, McMahon LG, Gregory JF. Pyridoxine-5’- beta-glucoside exhibits incomplete bioavailability as a source of vitamin B-6 and partially inhibits the utilization of co-ingested pyridoxine in humans. J Nutr. 1997;127(8):1508–1513
  35. Tandler B, Krhenbul S, Brass EP. Unusual mitochondria in the hepatocytes of rats treated with a vitamin B12 analogue. Anat Rec. 1991;231(1):1–6
  36. Holick, M. F. Vitamin D. Modern Nutrition in Health and Disease, 9th ed. Baltimore, William & Wilkins, 1999, 329, 345
  37. Thiel R. Vitamins are naturally found in food complexes. ANMA Monito. 1999;3(1):5–9
  38. Bauernfeind, J. C. Nutrification of foods. Modern Nutrition in Health and Disease, 8th ed. Philadelphia, Lea & Febiger, 1994, 1579, 1592
  39. Nitta Y, Kamiya K, Tanimoto M, Sadimoto S, Niwa O, Yokoro K. Induction of transplantable tumors by repeated injections of natural and synthetic vitamin E in mice and rats. Jpn J Cancer Res. 1991;82(5):511–517
  40. Ha SW. Rabbit study comparing yeast and isolated B vitamins (as described in Murray R. P. Natural vs. Synthetic. Mark R. Anderson, 1995:A3). Ann Rev Physiol. 1941;3:259–282
  41. Mack A. All vitamin supplements not created equal. Med Trib. 1998;17:
  42. Vinson JA, Bose P. Bioavailability of synthetic ascorbic acid and a citrus extract. Ann New York Academy of Sciences. 1987;
  43. Vinson JA, Staretz ME, Bose P, Kassm HM, Basalyga BS. In vitro and in vivo reduction of erythrocyte sorbitol by ascorbic acid. Diabetes. 1989;38:1036–1041
  44. Vinson JA, Howard TB. Inhibition of protein glycation and advanced glycation end products by ascorbic acid and other vitamins and nutrients. Nutr Bioch. 1996;7:659–663
  45. Vinson JA, Courey JM, Maro NP. Comparison of two forms of vitamin C on galactose cataracts. Nutrition Research. Pergamon Press; 1992; p. 915–922
  46. Traber MG, Elsner A, Brigelius-Flohe R. Synthetic as compared with natural vitamin E is preferentially excreted as alpha-CEHC in human urine: studies using deuterated alpha- tocopherol acetates. FEBS Letters. 1998;437:145–148
  47. Fallon MB, Boyer JL. Hepatic toxicity of vitamin A and synthetic retinoids. J Gastro Hepatol. 1990;5(3):334–342
  48. Rothman K, Moore LL, Singer MR, Nguyen US, Milunski A. Teratogenicity of high vitamin A intake. NEJM. 1995;333(21):1369–1373
  49. Hui JH. Encyclopedia of Food Science and Technology. New York: John Wiley,; 1992;
  50. Haynes, W. Chemical Trade Names and Commercial Synonyms, 2nd ed. New York, Van Nostrand Co, 1955
  51. Tanphaichitr, V. Thiamin. Modern Nutrition in Health and Disease, 9th ed. Baltimore, William & Wilkins, 1999, 381, 389
  52. Kimura M, Itokawa Y, Fujiwara M. Cooking losses of thiamin in food and its nutritional significance. J Nutr Sci Vitaminol. 1990;36(S1):S17:S24
  53. McCormick, D. B. Riboflavin. Modern Nutrition in Health and Disease, 9th ed. Baltimore, William & Wilkins, 1999, 391, 399
  54. Kanno C, Kanehara N, Shirafuji K, Tanji R, Imai T. Binding form of vitamin B2 in bovine milk: its concentrations, distribution, and binding linkages. J Nutr Sci Vitaminol. 1991;37(1):15–27
  55. Cervantes-Lauren, D. McElvaney, N. G. Moss, J. Niacin. Modern Nutrition in Health and Disease, 9th ed. Baltimore, William & Wilkins, 1999, 401, 411
  56. Williams, A. W. Erdman, J. W. Food processing: nutrition, safety, and quality balances. Modern Nutrition in Health and Disease, 9th ed. Baltimore, William & Wilkins, 1999, 1813, 1821
  57. Tenney, L. Health Handbook. Woodland Books, Provo (UT), 1987
  58. Plesofsky-Vig, N. Pantothenic acid. Modern Nutrition in Health and Disease, 9th ed. Baltimore, William & Wilkins, 1999, 423, 432
  59. Leklem, J. E. Vitamin B6. Modern Nutrition in Health and Disease, 9th ed. Baltimore, William & Wilkins, 1999, 413, 421
  60. Crane N, Wilson DB, Cook DA, Lewis CJ, Yetley EA, Rader JI. Evaluating food fortification options: general principles revisited with folic acid. Am J Public Health. 1995;85(5):660–666
  61. Tucker KL, Mahnken B, Wilson PW, Jaques P, Selhub J. Folic acid fortification. Potential benefits and risks for the elderly population. JAMA. 1997;276(23):1879–1885
  62. Maurer K. Group urges increased folic acid fortification. Family Practice News. 1996;11
  63. Mervyn, L. The B Vitamins. Thorsons, Wellingborough (UK), 1981
  64. Weir, D. G. Scott, J. M. Vitamin B12 “cobalamin”. Modern Nutrition in Health and Disease, 9th ed. Baltimore, William & Wilkins, 1999, 447, 458
  65. Vanderslice JT, Higgs DJ. Vitamin C content of foods: sample variability. Am J Clin Nutr. 1991;54(Supp 6):1323S–1327S
  66. Levine, M. Rumsey, S. Wang, Y. Vitamin C. Present Knowledge in Nutrition, 7th ed. Washington, ILSI Press, 1996, 146, 159
  67. Mangels A, Block G, Frey CM. The bioavailability to humans of ascorbic acid from oranges, orange juice and cooked broccoli is similar to that of synthetic ascorbic acid. J Nutr. 1993;123(6):1054–1061
  68. Johnson C, Luo B. Comparison of the absorption and excretion of three commercially available sources of vitamin C. J Am Diet Assoc. 1994;94:779–781
  69. Weisburger JH. Vitamin C and disease prevention. J Am Coll Nutr. 1995;14(2):109–111
  70. Davie SJ, Gould BJ, Yudkin JS. Effect of vitamin C on glycation of proteins. Diabetes. 1992;41:161–173
  71. Miyamoto K, Murayama E, Ochi K, Watanabe H, Kubodera N. Synthetic studies of vitamin D analogues. XIV. Synthesis and calcium regulating activity of vitamin D3 analogues bearing a hydroxlkoxy group at the 2 beta-position. Chem Pharm Bull. 1993;41(6):1111–1113
  72. Fioravanti L, Miodini P, Cappelletti V, DiFronzo G. Synthetic analogs of vitamin D3 have inhibitory effects on breast cancer cell lines. Anticancer Res. 1998;18:1703–1708
  73. J Am Diet Assoc. 1998;98(5):522
  74. Devaraj S, Adams-Huet B, Fuller CJ, Jialal I. Dose- response comparison of RRR-alpha-tocopherol and all-racemic alpha tocopherol on LDL oxidation. Arterioscler Thromb Vasc Biol. 1997;17:2273–2279
  75. Traber, M. G. Vitamin E. Modern Nutrition in Health and Disease, 9th ed. Baltimore, William & Wilkins, 1999, 347, 362
  76. J Am Diet Assoc. 1998;98(8):918
  77. Traber MG, Burton GW, Hughes L. Discrimination between forms of vitamin E by humans with and without genetic abnormalities of lipoprotein metabolism. J Lipid Res. 1992;33:1171–1182
  78. An Overview of Vitamin E Efficacy. VERIS Research Information Service, November 1998
  79. Dakshinamurti, K. Biotin. Modern Nutrition in Health and Disease, 8th ed. Philadelphia, Lea & Febiger, 1994, 426, 431
  80. Booth SL, Pennington JA, Sadowski JA. Food sources and dietary intakes of vitamin K-1 (phylloquinone) in the American diet: data from the FDA Total Diet Study. J Am Diet Assoc. 1996;96(2):149–154
  81. Booth SL, Pennington JA, Sadowski JA. Dihydro-vitamin K1: primary food sources and estimated dietary intakes in the American diet. Lipids. 1996;31:715–720
  82. Aschero A, Willett WC. Health affects of trans fatty acids. Am J Clin Nutr. 1997;66:1006S–1010S
  83. Turnland JR. Bioavailability of dietary minerals to humans: the stable isotope approach. Crit Rev Food Sci Nutr. 1991;30(4):387–396
  84. Bollet AJ. Politics and pellagra: the epidemic of pellagra in the U.S. in the early twentieth century. Yale. J Biol Med. 1992;65(3):211–221
  85. Erdman, J. W. Poneros-Schneir, A. G. Factors affecting the nutritive value in processed foods. Modern Nutrition in Health and Disease, 8th ed. Philadelphia, Lea & Febiger, 1994, 1569, 1578
  86. Schroeder, H. A. The Trace Elements and Man. Devin-Adair, New Greenwich (CT), 1973
  87. Leek R. Olestra? Just say no!. J ANMA AANC. 1996;1(1):21
  88. Daher GC, Cooper DA, Peters JC. Physical or temporal separation of olestra and vitamins A, E, and D intake decreases the effect of olestra on the status of the vitamins in the pig. J Nutr. 1997;127(8):1566S–1572S
  89. Schlagheck TG, Kesler JM, Jones MB. Olestra’s effect on vitamins D and E in humans can be offset by increasing dietary levels of these vitamins. J Nutr. 1997;127(8):1666S–1685S
  90. Andrews LS, Ahmedna M, Grodner RM. Food preservation using ionizing radiation. Rev Environ Contam Toxicol. 1998;154(1):1–53
  91. Ghebremeskel K, Crawford MA. Nutrition and health in relation to food production and processing. Nutr Health. 1994;9(4):237–253
  92. Herbert V. Vitamin supplements and disease-counterpoint. J Am Coll Nutr. 1995;14(2):112–113
  93. Kempster PA, Wahlquist ML. Dietary factors in the management of Parkinson’s disease. Nutr Reviews. 1994;52(2):51–58
  94. Ben-Amotz A. Effect of natural beta-carotene supplementation in children exposed to radiation from the Chernobyl accident. Radiat Environ Biophys. 1998;37:187–193
  95. Bendich A, Langseth L. The health effects of vitamin C supplementation: a review. J Am Coll Nutr. 1995;14(2):124–136
  96. Franceschi S, Parpinel M, La Vecchia C, Favero A, Talamini R, Negri E. Role of different types of vegetables and fruit in the prevention of cancer of the colon, rectum, and breast. Epidemiology. 1998;9(3):338–341
  97. Rautalahti M, Huttunen J. Antioxidants and carcinogenesis. Ann Med. 1993;25:435–441
  98. Lonn E, Yusuf S. Is there a role for antioxidant vitamins in the prevention of cardiovascular diseases? An update on epidemiological and clinical trials data. Can J Cardiology. 1994;13(10):957–965
  99. Jensen, B. The Chemistry of Man. Bernard Jensen, Escondido (CA), 1983
  100. DeCava, J. A. The Real Truth about Vitamins & Antioxidants. A Printery, Centerfield (MA), 1997
  101. Murray, R. P. Natural vs. Synthetic. Mark R. Anderson, 1995
  102. Cronquist A. Plantae. Synopsis and Classification of Living Organisms. NY: McGraw-Hill; 1982; p. 57
  103. Kennedy, E. The 1995 USDA/HHS Dietary Guidelines – An Overview. Washington, D.C. USDA, 1995

PII: S0306-9877(00)91090-9

doi: 10.1054/mehy.2000.1090

Medical Hypotheses
Volume 55, Issue 6 , Pages 461-469 , December 2000

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