Medical Hypotheses
Volume 55, Issue 6 , Pages 510-512 , December 2000

Alpha lipoic acid: a novel treatment for depression

Received 21 December 1999 ,Accepted 22 February 2000.

References 

    REFERENCES
  1. American Medical Association, Essential Guide to Depression. New York, Pocket Books, 1998
  2. McCarty MF. Enhancing central and peripheral insulin activity as a strategy for the treatment of endogenous depression – an adjuvant role for chromium picolinate. Med Hypotheses. 1994;43:247–252
  3. Estrada ED, Ewart SH, Tsakiridis T, Volchuk A, Ramlal T, Tritschler H, et al. Stimulation of glucose uptake by the natural coenzyme alpha lipoic acid/thioctic acid: participation of elements of insulin signaling pathway. Diabetes. 1996;45:1798–1804
  4. Winokur A, Maislin G, Phillips JK, Amsterdam JD. Insulin resistance after oral glucose testing in patients with major depression. American Journal of Psychiatry. 1988;145:325–330
  5. Wright JH, Jacisn JJ, Radin NA, Bell RA. Glucose metabolism in Unipolar Depression. British Journal of Psychiatry. 1978;132:386–393
  6. Nathan RS, Sachar EJ, Asns GM. Relative insulin insensitivity and cortisol secretion in depressed patients. Psychiatric Research. 1981;4:291–300
  7. Rothschild AJ. Biology of Depression. Med Clin North America. 1988;72:765–790
  8. Rubin RT, Poland RE, Lesser IM. Neuroendocrine aspects of primary endogenous depression. Archives of General Psychiatry. 1987;44:328–336
  9. Gavard JA, Lustman PJ, Cloise RE. Prevalence of depression in adults with diabetes: An epidemiological evaluation. Diabetes Care. 1993;16:1167–1178
  10. Lustman PJ, Griffith LS, Freedland KE, Clouse RE. The course of major depression in diabetics. Gen Hosp Psychiatry. 1997;19:138–143
  11. Geringer ES. Affective disorders and diabetes mellitus. In:  Homes CS editors. Neuropsychology and Behavioral Aspects of Diabetes. New York: Sringer-Verlag; 1990;p. 239–272
  12. Hudson JI, Hudson MS, Rothschild AJ. Abnormal results of dexamethasone suppression tests in nondepressed patients with diabetes mellitus. Archives of General Psychiatry. 1984;41:1086–1089
  13. Coppen A. The biochemistry of affective disorders. British Journal of Psychiatry. 1967;113:1237–1264
  14. Meltzer HY. Serotonergic Dysfunction in Depression. British Journal of Psychiatry. 1989;155:25–31
  15. Meltzer HY, Lowy MT. The serotonin hypothesis of depression. In:  Meltzer HY editors. Psychopharmacology, The Third Generation of Progress. New York: Raven Press; 1987;p. 513–526
  16. Koyama T, Meltzer HY. A biochemical and neuroendocrine study of the serotonergic system in depression. In:  Hippius H,  Klerman GL,  Matussek N editor. New Results in Depression Research. Berlin, New York: Springer-Verlag; 1986;p. 164–188
  17. Robins E, Gassner S, Kayes J, Wilkinson RH, Murphy GE. The communication of suicidal intent: A study of 134 consecutive cases of successful (completed) suicide. American Journal of Psychiatry. 1959;115:724–733
  18. Roy A, DeJong J, Linniola M. Cerebrospinal fluid monoamine metabolites and suicidal behavior in depressed patients. Arch Gen Psychiatry. 1989;46:609–612
  19. Asberg M, Bertilsson L, Martensson B. CSF monoamine metabolites in melancholia. Acta Psychiatrica Scandinavica. 1984;69:201–219
  20. Asberg M, Thoren P, Taskman L. ‘Serotonin depression’ – a biochemical subgroup within the affective disorders?. Science. 1976;191:478–480
  21. Carlsson A, Lindqvist M. The effect of L-tryptophan and some psychotropic drugs on the formation of 5-hydroxytryptophan in the mouse brain in vivo. Journal Neural Transmission. 1972;33:23–43
  22. Demyer MK, Shea PA, Hendred HC. Plasma tryptophan and five other amino acids in depressed and normal subjects. Archives of General Psychiatry. 1981;38:642
  23. Quintana J. Platelet serotonin and plasma tryptophan decreases in endogenous depression: Clinical, therapeutic, and biological correlations. Journal of Affective Disorders. 1992;24:55–62
  24. Delgado PL, Charney DS, Price LH, Aghajanian GK, Landis H, Hininger GR. Serotonin function and the mechanism of antidepressant action. Archives of General Psychiatry. 1990;47:411–418
  25. Chaouloff F. The serotonin hypothesis. In:  Morgan WP editors. Physical Activity and Mental Health. Washington, DC: Taylor and Francis; 1997;p. 179–198
  26. Fernstrom JD. The effect of nutritional factors on brain amino acid levels and monoamine synthesis. Fed Proc. 1976;35:1151–1156
  27. Trulson ME, MacKenzie RG. Increased tryptophan hydroxylase activity may compensate for decreased brain tryptophan levels in streptozotocin-diabetic rats. Experimental Therapy. 1980;212:269–273
  28. Chaouloff F, Laude D, Merino D, Serrurier B, Baudrie V, Elghozi JL. Duration of streptozotocin diabetes influences the response of hypothalamic serotonin metabolism to immobilization stress. Neuroendocrinology. 1989;50:344–350
  29. Mans AM, DeJoseph MR, Davis DW, Hawkins RA. Regional amino acid transport into brain during diabetes: effect of plasma amino acids. American Journal of Physiology. 1987;253:575–583
  30. Crandall EA, Gillis MA, Fernstrom JD. Reduction in brain serotonin synthesis rate in streptozotocin-diabetic rats. Endocrinology. 1981;109:310–312
  31. Henley WN, Bellush LL. Streptozotocin-induced decreases in serotonin turnover are prevented by thyroidectomy. Neuroendocrinology. 1992;56:354–363
  32. Broderick PA, Jacoby JH. Central monoamine dysfunction in diabetes: psychotherapeutic implications: electroanalysis by voltammetry. Acta Physiologica et Pharmacologica Latinoamericana. 1989;39:211–225
  33. Kern S, Engerman RL. Abnormal amino acid concentrations in plasma and urine of experimentally diabetic dogs. Research in Experimental Medicine. 1983;182:185–192
  34. Woodger TL, Sirek A, Anderson GH. Diabetes, dietary tryptophan, and protein intake regulation in weanling rats. American Journal of Physiology. 1979;236:307–311
  35. Jacob S, Henrisksen EJ, Schiemann AL, Simon I, Clancey DE, Tritschler HJ, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha lipoid acid. Arzneimittelforschung. 1995;45:872–874
  36. Jacob S, Streeper RS, Fogt DL, Hokama JY, Tritschler HJ, Dietze GJ, et al. The antioxidant alpha lipoic acid enhances insulin stimulated glucose metabolism in insulin- resistant skeletal muscle. Diabetes. 1996;45:1024–1029
  37. Khamaisi M, Potashnik R, Tirosh A, Demshchak E, Rudich A, Tritschler H, et al. Lipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin-diabetic mice. Metabolism. 1997;46:763–768
  38. Aberg-Wistedt A. The antidepressant effects of 5-HT uptake inhibitors. British Journal of Psychiatry. 1989;155:32–40

PII: S0306-9877(00)91103-4

doi: 10.1054/mehy.2000.1103

Medical Hypotheses
Volume 55, Issue 6 , Pages 510-512 , December 2000