Medical Hypotheses
Volume 56, Issue 2 , Pages 160-162, February 2001

A pendular mechanism for maintenance of the immune memory

Immunohematologic Department, Institute of Clinical Immunology, Novosibirsk, Russia

Received 15 September 1999; accepted 28 March 2000.

Abstract 

A possible mechanism for maintaining immune memory, based on idiotypic–anti-idiotypic interactions, is described. It is proposed that pendular dynamic swings in the levels of idiotypic antibodies (Ab1) and anti-idiotypic Ab2 may underlay immune memory. In the terms of the advanced concept, Ab dynamics in the maternal body might also play a significant role in education of the neonatal immune system.

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PII: S0306-9877(00)91132-0

doi:10.1054/mehy.2000.1132

Medical Hypotheses
Volume 56, Issue 2 , Pages 160-162, February 2001

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