Medical Hypotheses
Volume 55, Issue 5 , Pages 452-453 , November 2000

High-dose methylprednisolone may do more harm for spinal cord injury

  • T. Qian

      Affiliations

    • Department of Physical Medicine & Rehabilitation, UMDNJ – New Jersey Medical School, Newark, New Jersey, USA
    • ,
  • D. Campagnolo

      Affiliations

    • Department of Physical Medicine & Rehabilitation, UMDNJ – New Jersey Medical School, Newark, New Jersey, USA
    • ,
  • S. Kirshblum

      Affiliations

    • Kessler Institute for Rehabilitation, West Orange, New Jersey, USA

Received 3 February 2000 ,Accepted 1 June 2000.

References 

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  1. Bracken MB, Shepard MJ, Collins WF. A randomized control trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury. N Engl J Med. 1990;322:1405–1411
  2. Bracken MB, Shepard MJ, Holford TR. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. JAMA. 1997;299:1597–1604
  3. Nesathurai S. Steroids and spinal cord injury: revisiting the NASCIS 2 and NASCIS 3 trials. J Trauma. 1998;45:1088–1093
  4. Nava S, Gayan-Ramierez G, Rollier H. Effects of acute steroid administration on ventilatory and peripheral muscles in rats. Am J Respir Crit Care Med. 1996;153:1888–1896
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  7. Knox AJ, Mascie-Taylor BH, Muers M. Acute hydrocortisone myopathy in acute severe asthma. Thorax. 1986;41:411–412
  8. Williams TJ, O’Hehir RE, Czarny D. Acute myopathy in severe acute asthma treated with intravenously administered corticosteroid. Am Rev Respir Dis. 1988;137:460–463
  9. Griffin D, Fariman N, Coursin D. Acute myopathy during treatment of status asthmaticus with corticosteroids and steroidal muscle relaxants. Chest. 1992;102:510–514
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PII: S0306-9877(00)91165-4

doi: 10.1054/mehy.2000.1165

Medical Hypotheses
Volume 55, Issue 5 , Pages 452-453 , November 2000

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