Medical Hypotheses
Volume 56, Issue 6 , Pages 620-624 , June 2001

Immediate and longterm effects of immune stimulation: hypothesis linking the immune response to subsequent physical and psychological wellbeing

Received 26 April 2000 ,Accepted 5 September 2000.

References 

    REFERENCES
  1. Clausen CR, Munoz J, Bergman RK. A reaginic type of antibody stimulated by extracts of Bordetella pertussis in inbred strains of mice. J Immunol. 1970;104:312–319
  2. Mu HH, Sewell WA. Regulation of DTH and IgE responses by IL-4 and IFN-γ in immunized mice given pertussis toxin. Immunology. 1994;83:639–645
  3. Tada T, Okumura K, Ochia T, Iwasa S. Effect of lymphocytosis-promoting factor of Bordetella pertussis on the immune response. II. Adjuvant effect of the production of reaginic antibody in the rat. Int Arch of Allergy. 1972;43:207–216
  4. Mark A, Bjorksten B, Granstrom M. Immunoglobulin E responses to diphtheria and tetanus toxoids after booster with aluminium-adsorbed and fluid DT-vaccines. Vaccine. 1995;13:669–673
  5. Mark A, Bjorksten B, Granstrom M. Immunoglobulin E and G antibodies two years after a booster dose of an aluminium-adsorbed or a fluid DT vaccine in relation to atopy. Pediatric Allergy and Immunology. 1997;8:83–87
  6. Odelram H, Granstrom M, Hedenskig S, Duchen K, Bjorksten B. Immunoglobulin E and G responses to pertussis toxin after booster immunization in relation to atopy, local reactions and aluminium content of the vaccines. Pediatric Allergy and Immunology. 1994;5:118–123
  7. Nagel J, Svec D, Waters T, Fireman P. IgE synthesis in man. I. Development of specific IgE antibodies after immunization with tetanus diphtheria (TD) toxoids. J Immunol. 1977;118:334–341
  8. Cogne M, Ballet JJ, Schmitt C, Bizzine B. Total and IgE antibody levels following booster immunization with aluminum adsorbed and nonadsorbed tetanus toxoid in humans. Ann Allergy. 1985;54:148–151
  9. Howson, C. P. Howe, C. J. Fineberg, H. V. Adverse Effects of Pertussis and Rubella Vaccines: A Report of the Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines. National Academy Press, Washington, DC, 1991
  10. Collier LH, Polakoff S, Mortimer J. Reactions and antibody responses to reinforcing doses of adsorbed and plain tetanus vaccines. Lancet. 1979;1:1364–1368
  11. Jones AE, Melville-Smith M, Watkins J. Adverse reactions in adolescents to reinforcing doses of plain and adsorbed tetanus vaccines. Community Medicine. 1985;7:99–106
  12. White WG. Reactions after plain and adsorbed tetanus vaccines (letter). Lancet. 1980;1:42
  13. Facktor MA, Bernstein RA, Fireman P. Hypersensitivity to tetanus toxoid. J Allergy Clin Immunol. 1973;52:1–12
  14. Pappenheimer AM, Germanier R. Bacterial Vaccines. FL:: Academic Press, Orlando,; 1984;
  15. Stratton KR, Howe CJ, Johnston RB. Adverse Events Associated with Childhood Vaccines: Evidence Bearing on Causality. National Academy Press, Washington, DC:. 1994;
  16. Mu HH, Sewell WA. Enhancement of interleukin-4 production by pertussis toxin. Infect Immun. 1993;61:2834–2840
  17. Rook GAW, Standford JL. Give us this day our daily germs. Immunol Today. 1998;19:113–116
  18. Aebischer I, Stadler BM. TH1-TH2 cells in allergic responses: At the limits of a concept. Adv Immunology. 1996;61:341–403
  19. Munoz JJ, Sekura RD, Moss J, Vaughan M. Biological activities of pertussigen (pertussis toxin). eds. Pertussis Toxin. York:: Academic Press, New; 1985;
  20. Sen DK, Arora S, Gupta S, Sanyal RK. Studies of adrenergic mechanisms in relation to histamine sensitivity in children immunized with Bordetella pertussis vaccine. J Allergy Clin Immunol. 1974;54:25–31
  21. Prescott SL, Macaubas C, Yabuhara A, Venaille TJ, Holt BJ, Habre W, et al. Developing patterns of T cell memory to environmental allergens in the first two years of life. Int Arch Allergy Immunol. 1997;113:75–79
  22. Prescott SL, Macaubas C, Holt BJ, Smallacombe TB, Loh R, Sly PD, et al. Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T-cell responses towards the Th-2 cytokine profile. J Immunol. 1998;160:4730–4737
  23. Calderon MA, Devalia JL, Prior AJ, Sapsford RJ, Davies RJ. A comparison of cytokine release from epithelial cells cultured from nasal biopsy specimens of atopic patients with and without rhinitis and nonatopic subjects without rhinitis. J Allergy Clin Immunol. 1997;99:65–76
  24. Maggi E, Parronchi P, Roberts AM, Walker MR. Modulation of the functional properties of allergen-specific T cells by interferon-α and other cytokines. Allergic Mechanisms and Immunotherapeutic Strategies. Chichester, England: John Wiley and Sons Ltd; 1997; p. 177–192
  25. Besedovsky HO, Del Rey A. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr Rev. 1996;17:64–102
  26. Payne LC, Weigent DA, Blalock JE. Induction of pituitary sensitivity to interleukin-1: A new function for corticotropin-releasing hormone. Biochem Biophys Res Commun. 1994;198:480–484
  27. Roh MS, Drazenovic KA, Barbose JJ, Dinarello CA, Cobb CF. Direct stimulation of the adrenal cortex by interleukin-1. Surgery. 1987;102:140–146
  28. Bernton E, Hoover D, Galloway R, Popp K. Adaptation to chronic stress in military trainees: adrenal androgens, testosterone, glucocorticoids, IGF-1 and immune function. Ann NY Acad Sci. 1995;774:217–231
  29. Ramirez F, Fowell DJ, Puklavek M, Simmonds S, Mason D. Glucocorticoids promote a Th2 cytokine response by CD4+ T cells in vitro. J Immunol. 1996;156:2406–2412
  30. Wu CY, Sarfati M, Heusser C. Glucocorticoids increase the synthesis of immunoglobulin E by interleukin 4-stimulate human lymphocytes. J Clin Invest. 1991;87:870–877
  31. Del Rey A, Furukawa H, Monge-Arditi G, Kabiersch A, Voigt K-H, Besedovsky HO. Alterations in the pituitary-adrenal axis of adult mice following neonatal exposure to interleukin-1. Brain Beh Immun. 1996;10:235–248
  32. Schmidt ED, Janszen AWJW, Wouterlood FG, Tilders FJH. Interleukin-1-induced long-lasting changes in hypothalamic corticotropin-releasing hormone (CRH)–neurons and hyperresponsiveness of the hypothalamus-pituitary-adrenal axis. J Neuroscience. 1995;15:7417–7426
  33. Shintani F, Nakaki T, Kanba S, Kato R, Asai M. Role of interleukin-1 in stress responses: a putative neurotransmitter. Mol Neurobiol. 1995;10:47–71
  34. Theoharides TC, Singh LK, Boucher W, Pang X, Letourneau R, Webster E, et al. Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its proinflammatory effects. Endocrinology. 1998;139:403–413
  35. Papanicolaou DA, Wilder RL, Manolagas SC, Chrousos GP. The pathophysiologic roles of interleukin-6 in human disease. Ann Intern Med. 1998;128:127–137
  36. Zhou D, Shanks N, Riechman SE, Liang R, Kusnecov AW, Rabin BS. Interleukin 6 modulates interleukin-1-and stress-induced activation of the hypothalamic-pituitary-adrenal axis in male rats. Neuroendocrinology. 1996;63:227–236
  37. Checkley S. The neuroendocrinology of depression and chronic stress. BMB. 1996;52:597–617
  38. Lopez JF, Vasquez DM, Chalmers DT, Watson SJ. Regulation of 5-HT receptors and the hypothalamic-pituitary-adrenal axis: Implications for the neurobiology of suicide. Ann N Y Acad Sci. 1997;836:107–134
  39. Aguilera G. Regulation of pituitary ACTH secretion during chronic stress. Front Neuroendocrinol. 1994;15:321–350
  40. Dallman MF. Stress update. Adaptation of the hypothalamic-pituitary-adrenal axis to chronic stress. Trends Endocrinol Metab. 1993;4:62–69
  41. Dinan TG. Serotonin and the regulation of hypothalamic-pituitary-adrenal axis function. Life Sci. 1996;58:1683–1694
  42. Winberg S, Lepage O. Elevation of brain 5-HT activity, POMC expression, and plasma cortisol in socially subordinate rainbow trout. Am J Physiol. 1998;274:R645–R654
  43. Fishbain DA, Cutler R, Rosomoff HL, Rosomoff RS. Chronic pain-associated depression: antecedent or consequence of chronic pain? A review. The Clinical Journal of Pain. 1997;13:116–137
  44. DeLeo JA, Colburn RW, Weinstein JN, Gordon SL. The role of cytokines in nociception and chronic pain. Low back pain: A Scientific and Clinical Overview. IL:: American Academy of Orthopedic Surgeons, Rosemont,; 1996; p. p
  45. Kelley KW, Hutchison K, French R, Bluthe R-M, Parnet P, Johnson RW, et al. Central interleukin-1 receptors as mediators of sickness. Ann N Y Acad Sci. 1997;823:234–246
  46. Watkins LR, Wiertelak EP, Goehler LE, Mooney-Heiberger K, Martinez J, Furnes L, et al. Neurocircuitry of illness-induced hyperalgesia. Brain Res. 1994;693:283–299
  47. Maier SF, Watkins LR. Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock. Brain Res. 1995;695:279–282
  48. Watkins LR, Maier SF, Goehler LE. Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states. Pain. 1995;63:289–302
  49. Maes M, Bosmans E, Meltzer HY, Scharpe S, Suy E. Interleukin-1β: a putative mediator of HPA axis hyperactivity in major depression?. Am J Psychiatry. 1993;150:1189–1193
  50. Weinstock M. Does prenatal stress impair coping and regulation of hypothalamic-pituitary-adrenal axis?. Neurosci Biobehav Rev. 1997;21:1–10
  51. Reul JMHM, Stec I, Wiegers GJ, Labeur MS, Linthorst ACE, Arzt E. Prenatal immune challenge alters the hypothalamic-pituitary-adrenocortical axis in adult rats. J Clin Invest. 1994;93:2600–2607
  52. Plotsky PM, Meaney MJ. Early, post-natal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. Mol Brain Res. 1993;18:195–200
  53. Shanks N, LaRocque S, Meaney MJ. Neonatal endotoxin exposure alters the development of the hypothalamic-pituitary-adrenal axis: Early illness and later responsivity to stress. J Neurosci. 1995;15:376–384
  54. Blalock JE. The syntax of immune-neuroendocrine communication. Immunol Today. 1994;15:504–511
  55. Chover-Gonzalez AJ, Harbuz MS, Lightman SL. Effect of adrenalectomy and stress on interleukin-1β mediated activation of hypothalamic corticotropin releasing factor mRNA. J Neuroimmunol. 1993;42:155–160
  56. Harbuz MS, Conde GL, Marti O, Lightman SL, Jessop DS. The hypothalamic-pituitary-adrenal axis in autoimmunity. Ann N Y Acad Sci. 1997;823:215–224
  57. Sternberg EM, Chrousos GP, Wilder RL, Gold PW. The stress response and the regulation of inflammatory disease. Ann Intern Med. 1992;117:854–866
  58. Linthorst ACE, Flachskamm C, Hopkins SJ, Hoadley ME, Labeur MS, Holsboer F, et al. Long-term intracerebroventricular infusion of corticotropin-releasing hormone alters neuroendocrine, neurochemical, autonomic, behavioral, and cytokine responses to a systemic inflammatory challenge. J Neuroscience. 1997;17:4448–4460
  59. Odent MR, Culpin EE, Kimmel T. Pertussis vaccination and asthma: is there a link?. JAMA. 1994;272:592–593
  60. Kemp T, Pearce N, Fitzharris P, Crane J, Fergusson D, St.George I, et al. Is infant immunization a risk factor for childhood asthma or allergy?. Epidemiology. 1997;8:678–680
  61. Farooqi IS, Hopkin JM. Early childhood infection and atopic disorder. Thorax. 1998;53:927–932
  62. Nilsson L, Kjellman NI, Bjorksten B. A randomized controlled trial of the effect of pertussis vaccines on atopic disease. Arch Pediatr Adolesc Med. 1998;152:734–738
  63. Alm JS, Swartz J, Lilja G, Scheynius A, Pershagen G. Atopy in children of families with an anthroposophic lifestyle. Lancet. 1999;353:1485–1488
  64. Hurwitz EL, Morgenstern H. The effects of diphtheria-tetanus-pertussis (DTP) or tetanus vaccination on allergies and allergy-related respiratory symptoms among children and adolescents in the United States. J Manipulative Physiol Ther. 2000;23:81–90
  65. Nilsson L, Kjellman -IM, Storsaeter J, Gustafsson L, Olin P. Lack of association between pertussis vaccination and symptoms of asthma and allergy. JAMA. 1996;275:760
  66. Henderson J, North K, Griffiths M, Harvey I, Golding J. Pertussis vaccination and wheezing illnesses in young children: prospective cohort study. BMJ. 1999;318:1173–1176
  67. Hurwitz EL, Morgenstern H. Cross-sectional associations of asthma, hay fever, and other allergies with major depression and low-back pain among 20 to 39 year olds in the United States. Am J Epidemiol. 1999;150:1107–1116
  68. Cohen P, Pine DS, Must A, Kasen S, Brook J. Prospective associations between somatic illness and mental illness from childhood to adulthood. Am J Epidemiol. 1998;147:232–239

☆ Received 18 August 1998 Accepted 21 January 1999

☆☆ Correspondence to: Josef Zislin MD. Kfar Shaul Hospital, jerusalem, 91060

★ Correspondence to: Eric L. Hurwitz DC PhD, UCLA School of Public Health, Department of Epidemiology, Box 951772, Los Angeles, California 90095–1772, USA. Phone: (310) 206 4074; Fax: (310) 206 7371; E-mail: ehurwitz@ucla.edu

PII: S0306-9877(00)91217-9

doi: 10.1054/mehy.2000.1217

Medical Hypotheses
Volume 56, Issue 6 , Pages 620-624 , June 2001

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