Medical Hypotheses
Volume 56, Issue 6 , Pages 625-629 , June 2001

Renal regulation of plasma total antioxidant capacity

Received 15 June 2000 ,Accepted 5 September 2000.

References 

    REFERENCES
  1. Maesaka JK, Fishbane S. Regulation of renal urate excretion: a critical review. Am J Kidney Dis. 1998;32:917–933
  2. Johnson RJ, Kivlighn SD, Kim Y-G, Suga S, Fogo AB. Reappraisal of the pathogenesis and consequences of hyperuricemia in hypertension, cardiovascular disease, and renal disease. Am J Kidney Dis. 1999;33:225–234
  3. Curto R, Voit EO, Cascante M. Analysis of abnormalities in purine metabolism leading to gout and to neurological dysfunctions in man. Biochem. 1998;329:477–487
  4. ¡
  5. Wilk JB, Djousse L, Borecki I, Atwood LD, Hunt SC, Rich SS, et al. Segregation analysis of serum uric acid in the NHLBI family heart study. Hum Genet. 2000;106:355–359
  6. Tisler A, Pierratos A, Honey J, Bull SB, Logan AG. Hypertension aggregates in families of kidney stone patients with high urinary excretion of uric acid. J Hypertens. 1999;17:1853–1858
  7. Rantala, A. O. Kauma, H. Lilja, M. Savolainen, M. J. Reunanen, A. Kesaniemi, Y. A. Prevalence of the metabolic syndrome in drug-treated hypertensive patients and control subjects.
  8. Lip G, Beevers M, Beevers DG. Serum urate is associated with baseline renal dysfunction but not survival or deterioration in renal function in malignant phase hypertension. J Hypertension. 2000;18:97–101
  9. Nieto FJ, Iribarren C, Gross MD, Comstock GW, Cutler RG. Uric acid and serum antioxidant capacity: a reaction to atherosclerosis. Atherosclerosis. 2000;148:131–139
  10. Leyva F, Anker SD, Godsland IF, Teixeira M, Hellewell PG, Kox WJ, et al. Uric acid in chronic heart failure: a marker of chronic inflammation. Eur Heart J. 1998;19:1814–1822
  11. Alderman MH. Serum uric acid and cardiovascular disease risk. Ann Int Med. 2000;132:591
  12. Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Int Med. 1999;131:7–13
  13. Liese A, Hense H-W, Lowel H, Doring A, Tietze M, Keil U. Association of serum uric acid with all-cause and cardiovascular disease mortality and incident myocardial infarction in the MONICA Augsburg cohort. Epidemiology. 1999;10:391–397
  14. Fang J, Alderman MH. Serum uric acid and cardiovascular mortality. The NHANES I Epidemiology Follow-up Study, 1971–1992. J Am Med Assoc. 2000;283:2404–2410
  15. Elisaf M, Tsimichodimos V, Bairaktari E, Siamopoulos KC. Effect of micronized fenofibrate and losartan combination on uric acid metabolism in hypertensive patients with hyperuricemia. J cardiovasc Pharmacol. 1999;34:60–63
  16. Cutler RG. Urate and ascorbate: their possible roles as antioxidants om determining the longevity of species. Arch gerontol Geriatr. 1984;3:321–348
  17. Ames BN, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in human against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Nat Acad Sci (USA). 1981;78:6858–6862
  18. Hooper DC, Spitsin S, Kean RB, Champion JM, Dickson GM, Chaudhry I, et al. Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Proc Nat Acad Sci (USA). 1998;95:675–680
  19. Houston M, Chumley P, Radi R, Rubbo H, Freeman BA. Xanthine oxidase reaction with nitric oxide and peroxynitrite. Arch Biochem Biophys. 1998;355:1–8
  20. Rosell M, Regnstrom J, Kallner A, Hellenius M-L. Serum urate determines antioxidant capacity in middle-aged men – a controlled, randomized diet and exercise intervention study. J Int Med. 1999;246:219–226
  21. Wayner D, Burton GW, Ingold KU, Barclay L, Locke SJ. The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma. Biochim Biophys Acta. 1987;924:408–413
  22. Nyyssonen K, Porkkala-Sarataho E, Kaikkonen J, Salonen JT. Ascorbate and urate are the strongest determinants of plasma antioxidative capacity and serum lipid resistance to oxidation in Finnish men. Atherosclerosis. 1997;130:223–233
  23. Lussignoli S, Fraccaroli M, Andrioli G, Brocco G, Bellvite P. A microplate-based colorimetric assay of the total peroxyl radical trapping capacity of human plasma. Anal Biochem. 1999;269:38–44
  24. Jackson P, Loughrey CM, Lightbody JH, McNamee PT, Young IS. Effect of hemodialysis on total antioxidant capacity and serum antioxidants in patients with chronic renal failure. Clin Chem. 1995;41:1135–1138
  25. Sevanian A, Davies K, Hochstein P. Conservation of vitamin C by uric acid in blood. Free Rad Biol Med. 1985;1:117–124
  26. Schlotte V, Sevanian A, Hochstein P, Weithmann KU. Effect of uric acid and chemical analogues on oxidation of human low density lipoprotein in vitro. Free Rad Biol Med. 1998;25:839–847
  27. Karten B, Beisiegel U, Gercken G, Kontush A. Mechanism of lipid peroxidation in human blood plasma: a kinetic approach. Chem Physics Lipids. 1997;88:83–96
  28. Kristal BS, Vigneau-Callahan KE, Moskowitz AJ, Matson WR. Purine catabolism: links to mitochondrial respiration and antioxidant defenses?. Arch Biochem Biophys. 1999;370:22–33
  29. Brites FD, Evelson PA, Christiansen MG, Nicol MF, Basilico MJ, Wikinski RW, et al. Soccer players under regular training show oxidative stress but an improved plasma antioxidant status. Clin Sci. 1999;96:381–385
  30. Yao JK, Reddy R, van Kammen DP. Reduced level of plasma antioxidant uric acid in schizophrenia. Psych Res. 1998;80:29–39
  31. Ogihara T, Kim H-S, Hirano K, Imanishi M, Ogihara H, Tamai H, et al. Oxidative products of uric acid and ascorbic acid in preterm infants with chronic lung disease. Biol Neonate. 1998;73:24–33
  32. Mikami T, Yoshino Y, Ito A. Does a relationship exist between the urate pool in the body and lipid peroxidation during exercise?. Free Rad Res. 2000;32:31–39
  33. Briggs JP, Levitt MF, Abramson RG. Renal excretion of allantoin in rats: a micropuncture and clearance study. Am J Physiol. 1977;233:F373–F381
  34. J Am Med Assoc. 1991;265:3255–3264
  35. Wilcox CS. In:  Brenner BM,  Saunders WB editor. Diuretics. in The Kidney. 1996;p. 2299–2330
  36. Pecker MS. In:  Laragh JH,  Brenner BM editor. Pathophysiologic effects and strategies for long-term diuretic treatment of hypertension. in Hypertension: Pathophysiology, Diagnosis, and Management.. Raven Press; 1990;p. 2143–2167
  37. Caspi D, Lubart E, Graff E, Habot B, Yaron M, Segal R. The effect of mini-dose aspirin on renal function and uric acid handling in elderly patients. Arthritis Rheum. 2000;43:103–108
  38. Steinber FM, Chait A. Antioxidant vitamin supplementation and lipid peroxidation in smokers. Am J Clin Nutr. 1998;68:319–327
  39. Henning SM, Ingles S, Mahmoud M, Go V, Carlton E, Caulfield M, et al. Multivitamin and mineral supplement did not alter the antioxidant capacity in plasma of healthy young men and women. Nutr Res. 2000;20:167–176
  40. Santos C, Anjos EI, Augusto O. Uric acid oxidation by peroxynitrite: multiple reactions, free radical formation, and amplification of lipid oxidation. Arch Biochem Biophys. 1999;372:285–294
  41. ¡
  42. Puig Jg, Ruilope LM. Uric acid as a cardiovascular risk factor in arterial hypertension. J Hypertension. 1999;17:869–872
  43. Zhang Z, Blake DR, Stevens CR, Kanczler JM, Winyard PG, Symins M, et al. A reappraisal of xanthine dehydrogenase and oxidase in hypoxic reperfusion injury: the role of NADH as an electron donor. Free Rad Res. 1998;28:151–164

PII: S0306-9877(00)91221-0

doi: 10.1054/mehy.2000.1221

Medical Hypotheses
Volume 56, Issue 6 , Pages 625-629 , June 2001

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