Medical Hypotheses
Volume 57, Issue 2 , Pages 146-150 , August 2001

Insulin secretion as a determinant of pancreatic cancer risk

Received 17 August 2000 ,Accepted 9 January 2001.

References 

    REFERENCES
  1. Gold EB. Epidemiology of and risk factors for pancreatic cancer. Surg Clin North Am. 1995;75:819–843
  2. Noy A, Bilezikian JP. Clinical review 63: Diabetes and pancreatic cancer: clues to the early diagnosis of pancreatic malignancy. J Clin Endocrinol Metab. 1994;79:1223–1231
  3. Gapstur SM, Gann PH, Lowe W, Liu K, Colangelo L, Dyer A. Abnormal glucose metabolism and pancreatic cancer mortality [In Process Citation]. JAMA. 2000;283:2552–2558
  4. Bell RHJ, Sayers HJ, Pour PM, Ray MB, McCullough PJ. Importance of diabetes in inhibition of pancreatic cancer by streptozotocin. J Surg Res. 1989;46:515–519
  5. Bell RHJ, McCullough PJ, Pour PM. Influence of diabetes on susceptibility to experimental pancreatic cancer. Am J Surg. 1988;155:159–164
  6. Fisher WE, Boros LG, Schirmer WJ. Insulin promotes pancreatic cancer: evidence for endocrine influence on exocrine pancreatic tumors. J Surg Res. 1996;63:310–313
  7. Roebuck BD, Baumgartner KJ, MacMillan DL. Caloric restriction and intervention in pancreatic carcinogenesis in the rat. Cancer Res. 1993;53:46–52
  8. Fisher WE, Boros LG, O’Dorisio TM, O’Dorisio MS, Schirmer WJ. GI hormonal changes in diabetes influence pancreatic cancer growth. J Surg Res. 1995;58:754–758
  9. Ketelslegers JM, Maiter D, Maes M, Underwood LE, Thissen JP. Nutritional regulation of the growth hormone and insulin-like growth factor-binding proteins. Horm Res. 1996;45:252–257
  10. Frystyk J, Hussain M, Skjaerbaek C, Schmitz O, Christiansen JS, Froesch ER. Serum free IGF-I during a hyperinsulinemic clamp following 3 days of administration of IGF-I vs. saline. Am J Physiol. 1997;273:E507–E513
  11. McCarty MF. Up-regulation of IGF binding protein-I as an anticarcinogenic strategy: relevance to caloric restriction, exercise, and insulin sensitivity. Med Hypotheses. 1997;48:297–308
  12. Ghadirian P, Thouez JP, PetitClerc C. International comparisons of nutrition and mortality from pancreatic cancer. Cancer Detect Prev. 1991;15:357–362
  13. Lin Y, Tamakoshi A, Wakai K, Kawamura T. Descriptive epidemiology of pancreatic cancer in Japan. J Epidemiol. 1998;8:52–59
  14. Devesa SS, Silverman DT. Cancer incidence and mortality trends in the United States: 1935–74. J Natl Cancer. 1978;60:545–571
  15. Rabinowitz D, Merimee TJ, Maffezzoli R, Burgess JA. Patterns of hormonal release after glucose, protein, and glucose plus protein. Lancet. 1966;2:454–456
  16. McCarty MF. The origins of Western obcsity: a role for animal protein?. Med Hypotheses. 2000;54:488–494
  17. McCarty MF. Vegan proteins may reduce risk of cancer, obesity, and cardiovascular disease by promoting increased glucagon activity [In Process Citation]. Med Hypotheses. 1999;53:459–485
  18. Remer T, Pietrzik K, Manz F. A moderate increase in daily protein intake causing an enhanced endogenous insulin secretion does not alter circulating levels or urinary excretion of dehydroepiandrosterone sulfate. Metabolism. 1996;45:1483–1486
  19. Hardinge MG, Crooks H, Stare FJ. Nutritional studies of vegetarians. J Am Diet Assoc. 1966;48:25–28
  20. Thorogood M, McPherson K, Mann J. Relationship of body mass index, weight and height to plasma lipid levels in people with different diets in Britain. Community Med. 1989;11:230–233
  21. Campbell TC, Chen J. Energy balance: interpretation of data from rural China. Toxicol Sci. 1999;52:87–94
  22. Underwood LE, Thissen JP, Lemozy S, Ketelslegers JM, Clemmons DR. Hormonal and nutritional regulation of IGF-I and its binding proteins. Horm Res. 1994;42:145–151
  23. Harp JB, Goldstein S, Phillips LS. Nutrition and somatomedin. XXIII. Molecular regulation of IGF-I by amino acid availability in cultured hepatocytes. Diabetes. 1991;40:95–101
  24. Jousse C, Bruhat A, Ferrara M, Fafournoux P. Physiological concentration of amino acids regulates insulin-like-growth-factor-binding protein 1 expression. Biochem. 1998;334:147–153
  25. Carter JP, Saxe GP, Newbold V, Peres CE, Campeau RJ, Bernal-Green L. Hypothesis: dietary management may improve survival from nutritionally linked cancers based on analysis of representative cases. J Am Coll Nutr. 1993;12:209–226
  26. Ludwig DS, Majzoub JA, Al-Zahrani A, Dallal GE, Blanco I, Roberts SB. High glycemic index foods, overeating, and obesity. Pediatrics. 1999;103:E26
  27. Hannah JS, Dubey AK, Hansen BC. Postingestional effects of a high-protein diet on the regulation of food intake in monkeys. Am J Clin Nutr. 1990;52:320–325
  28. Skov AR, Toubro S, Ronn B, Holm L, Astrup A. Randomized trial on protein vs carbohydrate in ad libitum fat reduced diet for the treatment of obesity. Int J Obes Relat Metab Disord. 1999;23:528–536
  29. Slabber M, Barnard HC, Kuyl JM, Dannhauser A, Schall R. Effects of a low-insulin-response, energy-restricted diet on weight loss and plasma insulin concentrations in hyperinsulinemic obese females. Am J Clin Nutr. 1994;60:48–53
  30. Garg A, Bonanome A, Grundy SM, Zhang ZJ, Unger RH. Comparison of a high-carbohydrate diet with a high-monounsaturated-fat diet in patients with non-insulin-dependent diabetes mellitus. N Engl J Med. 1988;319:829–834
  31. Garg A, Bantle JP, Henry RR, Coulston AM. Effects of varying carbohydrate content of diet in patients with non-insulin-dependent diabetes mellitus [see comments]. JAMA. 1994;271:1421–1428
  32. Bushman JL. Green tea and cancer in humans: a review of the literature. Nutr Cancer. 1998;31:151–159
  33. Jones PJ, Pencharz PB, Clandinin MT. Whole body oxidation of dietary fatty acids: implications for energy utilization. Am J Clin Nutr. 1985;42:769–777
  34. Leyton J, Drury PJ, Crawford MA. Differential oxidation of saturated and unsaturated fatty acids in vivo in the rat [published erratum appears in Br J Nutr 1987 Sep: 58 (2): following 331]. Br J Nutr. 1987;57:383–393
  35. Bell RR, Spencer MJ, Sherriff JL. Voluntary exercise and monounsaturated canola oil reduce fat gain in mice fed diets high in fat. J Nutr. 1997;127:2006–2010
  36. Maron DJ, Fair JM, Haskell WL. Saturated fat intake and insulin resistance in men with coronary artery disease. The Stanford Coronary Risk Intervention Project Investigators and Staff. Circulation. 1991;84:2020–2027
  37. Parker DR, Weiss ST, Troisi R, Cassano PA, Vokonas PS, Landsberg L. Relationship of dietary saturated fatty acids and body habitus to serum insulin concentrations: the Normative Aging Study. Am J Clin Nutr. 1993;58:129–136
  38. Mayer EJ, Newman B, Quesenberry CPJ, Selby JV. Usual dietary fat intake and insulin concentrations in healthy women twins. Diabetes Care. 1993;16:1459–1469
  39. Barnard RJ, Ugianskis EJ, Martin DA, Inkeles SB. Role of diet and exercise in the management of hyperinsulinemia and associated atherosclerotic risk factors. Am J Cardiol. 1992;69:440–444
  40. Barnard RJ, Massey MR, Cherny S, O’Brien LT, Pritikin N. Long-term use of a high-complex-carbohydrate, high-fiber, low-fat diet and exercise in the treatment of NIDDM patients. Diabetes Care. 1983;6:268–273
  41. Ornish D, Brown SE, Scherwitz LW, Billings JH. Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial [see comments]. Lancet. 1990;336:129–133
  42. Nicholson AS, Sklar M, Barnard ND, Gore S, Sullivan R, Browning S. Toward improved management of NIDDM: A randomized, controlled, pilot intervention using a lowfat, vegetarian diet. Prev Med. 1999;29:87–91
  43. Barnard N. Food for Life – How the New Four Food Groups Can Save Your Life. New York: Three Rivers Press,. 1993;
  44. Robbins, J. Diet for a New America. New York, H. J. Kramer, 1998
  45. Olsen GW, Mandel JS, Gibson RW, Wattenberg LW, Schuman LM. Nutrients and pancreatic cancer: a population-based case-control study. Cancer Causes Control. 1991;2:291–297
  46. Bueno d. MH, Maisonneuve P, Runia S, Moerman CJ. Intake of foods and nutrients and cancer of the exocrine pancreas: a population-based case-control study in The Netherlands. Int J Cancer. 1991;48:540–549
  47. Kise Y, Yamamura M, Kogata M. Inhibitory effect of selenium on hamster pancreatic cancer induction by N¢-nitrosobis(2-oxopropyl)amine. Int J Cancer. 1990;46:95–100
  48. Appel MJ, Roverts G, Woutersen RA. Inhibitory effects of micronutrients on pancreatic carcinogenesis in azaserine-treated rats. Carcinogenesis. 1991;12:2157–2161
  49. Ji BT, Chow WH, Hsing AW. Green tea consumption and the risk of pancreatic and colorectal cancers. Int J Cancer. 1997;70:255–258
  50. Hiura A, Tsutsumi M, Satake K. Inhibitory effect of green tea extract on the process of pancreatic carcinogenesis induced by N-nitrosobis-(2-oxypropyl)amine (BOP) and on tumor promotion after transplantation of N-nitrosobis-(2-hydroxypropyl)amine (BHP)-induced pancreatic cancer in Syrian hamsters. Pancreas. 1997;15:272–277
  51. Burney PG, Comstock GW, Morris JS. Serologic precursors of cancer: serum micronutrients and the subsequent risk of pancreatic cancer. Am J Clin Nutr. 1989;49:895–900
  52. Birt DF, Pelling JC, Pour PM, Tibbels MG, Schweickert L, Bresnick E. Enhanced pancreatic and skin tumorigenesis in cabbage-fed hamsters and mice. Carcinogenesis. 1987;8:913–917
  53. Birt DF, Julius AD, Runice CE, White LT, Lawson T, Pour PM. Enhancement of BOP-induced pancreatic carcinogenesis in selenium-fed Syrian golden hamsters under specific dietary conditions. Nutr Cancer. 1988;11:21–33

PII: S0306-9877(01)91316-7

doi: 10.1054/mehy.2001.1316

Medical Hypotheses
Volume 57, Issue 2 , Pages 146-150 , August 2001

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