Medical Hypotheses
Volume 57, Issue 2 , Pages 183-185 , August 2001

Can glucose-insulin-potassium regimen suppress inflammatory bowel disease?

Received 28 September 2000 ,Accepted 17 January 2001.

References 

    REFERENCES
  1. Das UN. Beneficial action(s) of eicosapentaenoic acid/docosahexaenoic acid and nitric oxide in systemic lupus erythematosus. Med Sci Res. 1995;23:723–726
  2. Bell S, Kamm MA. Antibodies to tumor necrosis factor α as treatment for Crohn’s disease. Lancet. 2000;355:858–860
  3. Evans RC, Clarke L, Heath P. Treatment of ulcerative colitis with an engineered human anti-TNFalpha antibody CDP571. Aliment Pharmacol Ther. 1997;11:1031–1035
  4. Das UN. Possible beneficial action(s) of glucose-insulin-potassium regimen in acute myocardial infarction and inflammatory conditions: a hypothesis. Diabetologia. 2000;43:1081–1082
  5. Satomi N, Sakurai A, Haranaka K. Relationship of hypoglycemia to tumor necrosis factor production and antitumor activity: role of glucose, insulin, and macrophages. J Natl Cancer Inst. 1985;74:1255–1260
  6. Fraker DL, Merino MJ, Norton JA. Reversal of the toxic effects of cachectin by concurrent insulin administration. Am J Physiol. 1989;2566:E725–731
  7. Ottlecz A, Koltai M, Blazso G, Minker E. Contribution to the regulatory role of insulin in inflammation and anaphylaxis. Int Arch Allergy Appl Immunol. 1978;56:284–286
  8. Ottlecz A, Koltai M, Gecse A. Further studies on the anti-inflammatory effect of insulin. Agents Actions. 1977;7:487–491
  9. Ottlecz A, Gecse A, Koltai M, West GB. Involvement of the kinin system in the insulin-induced inhibition of carrageenin oedema in rats. Monogr Allergy. 1977;12:131–137
  10. Biochot E, Sannomiya P, Escofier N. Endotoxin-induced acute lung injury in rats. Role of insulin. Pulm Pharmacol Ther. 1999;12:285–290
  11. Kuboki K, Jiang ZY, Takahara N. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: a specific vascular action of insulin. Circulation. 2000;101:676–681
  12. Perner A, Rask-Madsen J. Review article: the potential role of nitric oxide in chronic inflammatory bowel disorders. Aliment Pharmacol Ther. 1999;13:135–144
  13. Rachmilewitz D, Stamler JS, Bachwich D. Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn’s disease. Gut. 1995;36:718–723
  14. Kojda G, Harrison D. Interaction between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure. Cardiovasc Res. 1999;43:562–571
  15. Aljada A, Saadeh R, Assian E, Ghanim H, Dandona P. Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide. J Clin Endocrinol Metab. 2000;85:2572–2575
  16. Mahony SM, Tisdale MJ. Reversal of weight loss induced by tumor necrosis factor-alpha. Cancer Lett. 1989;45:167–172
  17. Stenson WF, Cort D, Rodgers J, Burakoff R. Dietary supplementation with fish oil in ulcerative colitis. Ann Intern Med. 1992;116:609–614
  18. Kumar GS, Das UN. Effect of prostaglandins and their precursors on the proliferation of human lymphocytes and their secretion of tumor necrosis factor and various interleukins. Prostaglandins Leukotrienes Essen Fatty Acids. 1994;50:331–334
  19. Endres S, Ghorbani R, Kelley VE. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med. 1989;320:265–271
  20. Das UN. Beneficial effect of eicosapentaenoic acid and docosahexaenoic acid in the management of systemic lupus erythematosus and its relationship to the cytokine net work. Prostaglandins Leukotrienes Essen Fatty Acids. 1994;51:207–213

PII: S0306-9877(01)91334-9

doi: 10.1054/mehy.2001.1334

Medical Hypotheses
Volume 57, Issue 2 , Pages 183-185 , August 2001

Article Tools