Medical Hypotheses
Volume 57, Issue 5 , Pages 532-538, November 2001

Vaccines and the risk of insulin-dependent diabetes (IDDM): potential mechanism of action

  • J.B. Classen

      Affiliations

    • Classen Immunotherapies Inc. Baltimore, Maryland, USA
    • ,
  • D.C. Classen

      Affiliations

    • Division of Infectious Diseases, LDS Hospital and University of Utah School of Medicine, Salt Lake City, Utah, USA

Received 28 July 2000; accepted 23 January 2001.

Abstract 

Immunization with a number of different vaccines, including live and killed vaccines, has been linked to the development of insulin-dependent (type 1) diabetes in humans and animals. Multiple different mechanisms have been proposed to explain the association between vaccines and diabetes. The current paper reviews multiple different mechanisms by which vaccines are known to manipulate the immune system and can induce an autoimmune disease such as type 1 diabetes. Genetic variability may determine which of these pathways, or possible other pathways, predominate in an individual following immunization.

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  • f1 Correspondence to: John Barthelow Classen MD MBA, President and Chief Executive Officer, Classen Immunotherapies Inc., 6517 Montrose Avenue, Baltimore, MD 21212, USA. Phone: +1 410 377 4549; Fax: +1 410 377 8526; E-mail: Classen@vaccines.net

PII: S0306-9877(01)91352-0

doi:10.1054/mehy.2001.1352

Medical Hypotheses
Volume 57, Issue 5 , Pages 532-538, November 2001

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