Medical Hypotheses
Volume 58, Issue 1 , Pages 6-8 , January 2002

Ovarian interleukin-1-induced gene expression: privileged genes threshold theory

  • S Kol

      Affiliations

    • Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel
  • ,
  • I Kehat

      Affiliations

    • Department of Physiology, Faculty of Medicine, Technion, Haifa, Israel
  • ,
  • E.Y Adashi

      Affiliations

    • Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah, USA

Received 9 August 2000 ,Accepted 13 February 2001.

References 

  1. Espey LL. Ovulation as an inflammatory reaction – a hypothesis. Biol Reprod. 1980;22:73–106
  2. Hurwitz A, Ricciarelli E, Botero L, Rohan RM, Hernandez ER, Adashi EY. Endocrine- and autocrine-mediated regulation of rat ovarian (theca-interstitial) interleukin-1-gene expression: gonadotropin-dependent preovulatory acquisition. Endocrinology. 1991;129:3427–3429
  3. Dinarello CA, Sheldon MW. The role of interleukin-1 in disease. N Engl J Med. 1993;28:106–113
  4. Ben-Shlomo I, Adashi EY. Interleukin-1 as a mediator in the ovulatory sequence: evidence for a meaningful role of cytokines in ovarian physiology. Curr Sci Ser. 1994;1:187–192
  5. Brannstrom M, Wang L, Norman RJ. Ovulatory effect of interleukin-1 on the perfused rat ovary. Endocrinology. 1993;132:399–404
  6. Takehara Y, Dharmarajan AM, Kaufman G, Wallach EE. Effects of interleukin-1-on ovulation in the in vitro perfused rabbit ovary. Endocrinology. 1994;134:1788–1793
  7. Peterson CM, Hales HA, Hatasaka HH, Mitchell MD, Rittenhouse L, Jones KP. Interleukin-1-(IL-1β) modulates prostaglandin production and the natural IL-1 receptor antagonist inhibits ovulation in the optimally stimulated rat ovarian perfusion model. Endocrinology. 1993;133:2301–2306
  8. Simon C, Tsafriri A, Chun S-Y, Piquette GN, Dang W, Polan ML. Interleukin-1 receptor antagonist suppresses hCG-induced ovulation in the rat. Biol Reprod. 1994;51:662–667
  9. Hurwitz A, Loukides J, Ricciarelli E. Human intraovarian interleukin-1 (IL-1) system: highly-compartmentalized and hormonally-dependent regulation of the genes encoding IL-1, its receptor, and its receptor antagonist. J Clin Invest. 1992;89:1746–1754
  10. Simon C, Frances A, Piquette G, Polan ML. Immunohistochemical localization of the interleukin-1 system in the mouse ovary during follicular growth, ovulation, and luteinization. Biol Reprod. 1994;50:449–457
  11. Scherzer WJ, Ruutiainen-Altman KSL, Putowski LT, Kol S, Adashi EY, Rohan RM. Detection and in vivo hormonal regulation of rat ovarian type I and type II interleukin-1 receptor mRNAs: increased expression during the periovulatory period. J Soc Gynecol Invest. 1995;3:131–140
  12. Deyerle KL, Sims JE, Dower SK, Bothwell MA. Pattern of IL-1 receptor gene expression suggests role in non-inflammatory processes. J Immunol. 1992;149:1657–1665
  13. Polan ML, Loukides JA, Honig J. Interleukin-1 in human ovarian cells and in peripheral blood monocytes increases during the luteal phase: evidence for a midcycle surge in the human. Am J Obstet Gynecol. 1994;170:1000–1007
  14. Brannstrom M, Norman RJ, Seamark RF, Robertson SA. Rat ovary produces cytokines during ovulation. Biol Reprod. 1994;50:88–94
  15. Brannstrom M, Wang L, Norman RJ. Effects of cytokines on prostaglandin production and steroidogenesis of incubated preovulatory follicles of the rat. Biol Reprod. 1993;48:165–171
  16. Pitzel L, Jarry H, Wuttke W. Effects and interactions of prostaglandin F2, oxytocin, and cytokines on steroidogenesis of porcine luteal cells. Endocrinology. 1993;132:751–756
  17. Townson DH, Pate JL. Regulation of prostaglandin synthesis by interleukin-1 in cultured bovine luteal cells. Biol Reprod. 1994;51:480–485
  18. Kokia E, Hurwitz A, Ricciarelli E. Interleukin-1 stimulates ovarian prostaglandin biosynthesis: evidence for heterologous contact-independent cell-cell interaction. Endocrinology. 1992;130:3095–3097
  19. Kokia E, Hurwitz A, Ben-Shlomo I, Adashi EY, Yanagishita M. Receptor mediated stimulatory effects of IL-1β on hyaluronic acid and proteoglycan biosynthesis by cultured rat ovarian cells: role for heterologous cell-cell interactions. Endocrinology. 1993;133:2391–2394
  20. Hurwitz A, Dushnik M, Solomon H. Cytokine-mediated regulation of rat ovarian function: interleukin-1 stimulates the accumulation of 92-kD gelatinase. Endocrinology. 1993;132:2709–2714
  21. Hurwitz A, Finci-Yeheskel Z, Dushnik M. Cytokine-mediated regulation of rat ovarian function: interleukin-1 inhibits plasminogen activator activity through the stimulation of plasminogen activator inhibitor-1 (PAI-1). Mol Cell Endocrinol. 1994;101:307–315
  22. Ellman C, Corbett JA, Misko TP, McDaniel M, Beckerman KP. Nitric oxide mediates interleukin-1-induced cellular cytotoxicity in the rat ovary: a potential role for nitric oxide in the ovulatory process. J Clin Invest. 1993;92:3053–3056
  23. Ben-Shlomo I, Kokia E, Jackson M, Adashi EY, Payne DW. Interleukin-1? stimulates nitrate production in the rat ovary: evidence for heterologous cell–cell interaction and for insulin-mediated regulation of the inducible isoform of nitric oxide synthase. Biol Reprod. 1994;51:310–318
  24. Ben-Shlomo I, Adashi EY, Payne DW. The morphogenic/cytotoxic and prostaglandin-stimulating activities of interleukin-1β in the rat ovary are nitric oxide-independent. J Clin Invest. 1994;94:1463–1469
  25. Kol S, Ruutiainen-Altman K, Scherzer WJ. The rat intraovarian interleukin (IL)-1 system: cellular localization, cyclic variation and hormonal regulation of IL-1beta and of the type I and type II IL-1 receptors. Mol Cell Endocrinol. 1999;149:115–128
  26. Kol S, Donesky BW, Ruutiainen-Altman K. Ovarian interleukin-1 receptor antagonist in rats: gene expression, cellular localization, cyclic variation, and hormonal regulation of a potential determinant of interleukin-1 action. Biol Reprod. 1999;61:274–282
  27. Kol S, Ben-Shlomo I, Ruutianen K. The midcycle increase in ovarian glucose uptake is associated with enhanced expression of glucose transporter 3. J Clin Invest. 1997;99:2274–2283
  28. Kol S, Ben-Shlomo I, Ando M, Payne DW, Adashi EY. Interleukin-1b stimulates ovarian phospholipase A2 (PLA2) expression and activity: up-regulation of both secretory and cystosolic PLA2. Endocrinology. 1997;138:314–321
  29. Kol S, Ruutiainen K, Ben-Shlomo I, Ando M, Payne DW, Adashi EY. The rat ovarian phospholipase A2 system: gene expression, cellular localization, activity characterization, and interleukin-1 dependence. Endocrinology. 1997;138:322–331
  30. Ando M, Kol S, Kokia E. Rat ovarian prostaglandin endoperoxide synthase-1 and -2: periovulatory expression of granulosa cell-based interleukin-1-dependent enzymes. Endocrinology. 1998;139:2501–2508
  31. Pruzanski W, Vadas P. Phospholopase A2-mediator between proximal and distal effectors of inflammation. Immunol Today. 1991;12:143–146

PII: S0306-9877(01)91389-1

doi: 10.1054/mehy.2001.1389

Medical Hypotheses
Volume 58, Issue 1 , Pages 6-8 , January 2002