Medical Hypotheses
Volume 58, Issue 1 , Pages 28-33 , January 2002

Weight-loss drugs and supplements: are there safer alternatives?

Received 30 April 2001 ,Accepted 5 July 2001.

References 

  1. Seidell JC. Obesity, insulin resistance and diabetes – a worldwide epidemic. Br J Nutr. 2000;83:S5–S8
  2. Strano-Paul L, Phanumas D. Diabetes management. Analysis of the American Diabetes Association's clinical practice recommendations. Geriatrics. 2000;55:57–62
  3. Steffee CH, Singh HK. Chitwood Histologic changes in three explanted native cardiac valves following use offenfluramines WR. Cardiovasc Pathol. 1999;8:245–253
  4. Suvachittanont W, Jaranchavanapet P. Mitogenic effect of. Parkia speciosa. seed lectin on human lymphocytes.;66:699–704
  5. Brudnak, M. A. Application of genomeceuticals to the molecular and immunological aspects of autism, Med Hypotheses
  6. Hansawasdi C, Kawabata J, Kasai T. Alpha-amylase inhibitors from roselle (Hibiscus sabdariffa Linn.). Biosci Biotechnol Biochem. 2000;64:1041–1043
  7. Brudnak MA. Cancer preventing properties of essential oil monoterpenes D-limonene and perillyl alcohol. Poss Health. 2000;53:23–25
  8. Von Burg R. Limonene. J Appl Toxicol. 1995;15:495–499
  9. Hohl RJ. Monoterpenes as regulators of malignant cell proliferation. Adv Exp Med Biol. 1996;401:137–146
  10. Brichard SM, Henquin JC, Girard J. Phlorizin treatment of diabetic rats partially reverses the abnormal expression of genes involved in hepatic glucose metabolism. Diabetologia. 1993;36:292–298
  11. Goda T. Regulation of the expression of carbohydratedigestion/absorption-related genes. Br J Nutr. 2000;84:S245–S248
  12. Seberger PJ, Chaney WG. Control of metastasis by Asn-linked, beta 1-6 branched oligosaccharides in mouse mammary cancer cells. Glycobiology. 1999;9:235–241
  13. Osaki S, Kimura T, Sugimoto T, Hizukuri S, Iritani N. L-arabinose feeding prevents increases due to dietary sucrose in lipogenic enzymes and triacylglycerol levels in rats. J Nutr. 2001;131:796–799
  14. Seri K, Sanai K, Matsuo N, Kawakubo K, Xue C, Inoue S. L-arabinose selectively inhibits intestinal sucrase in an uncompetitive manner and suppresses glycemic response after sucrose ingestion in animals. Metabolism. 1996;45:1368–1374
  15. Bitou N, Ninomiya M, Tsujita T, Okuda H. Screening of lipase inhibitors from marine algae. Lipids. 1999;34:441–445
  16. Yamamoto M, Shimura S, Itoh Y, Ohsaka T, Egawa M, Inoue S. Anti-obesity effects of lipase inhibitor CT-II, an extract from edible herbs, Nomame Herba, on rats fed a high-fat diet. Int J Obes Relat Metab Disord. 2000;24:758–764
  17. Luppi PH, Aston-Jones G, Akaoka H, Chouvet G, Jouvet M. Afferent projections to the rat locus coeruleus demonstrated by retrograde andanterograde tracing with cholera-toxin B subunit and. Phaseolus vulgaris. leucoagglutinin.;65:119–160
  18. Imada H, Norimura T. , Influence of PHA stimulation on the cytotoxicity and mutagenicity of X-rays and ethylnitrosourea in human peripheral blood T-lymphocytes. Mutat Res. 1994;310:55–64
  19. Greer F, Brewer AC, Pusztai A. Effect of kidney bean (Phaseolus vulgaris) toxin on tissue weight and composition and some metabolic functions of rats. Br J Nutr. 1985;54:95–103
  20. Pousztai A, Clarke EM, King TP. The nutritional toxicity of Phaseolus vulgaris lectins. Proc Nutr Soc. 1979;38:115–120
  21. Di Virgilio S, Hellmann KP, Robberecht P. Multiple differences between wild-type B16 melanoma cells and a wheat germ agglutinin resistant clone. Anticancer Res. 1991;11:1815–1821
  22. Ishikawa M, Dennis JW, Man S, Kerbel RS. Isolation and characterization of spontaneous wheat germ agglutinin-resistant human melanoma mutants displaying remarkably different metastatic profiles in nude mice. Cancer Res. 1988;48:665–670
  23. Sayama K, Lin S, Zheng G, Oguni I. Effects of green tea on growth, food utilization and lipid metabolism in mice. In Vivo. 2000;14:481–484
  24. Sanai K, Seri K, Inoue S. Inhibition of sucrose digestion and absorption by L-arabinose in rats. J Jpn Soc Nutr Food Sci. 1997;50:133–137
  25. Huis in't Veld JH, Havenaar R, Marteau P. Establishing a scientific basis for probiotic R&D. Trends Biotechnol. 1994;12:6–8
  26. Gobbetti M, Lavermicocca P, Minervini F, de A, Corsetti A. Arabinose fermentation by Lactobacillus plantarum in sourdough with added pentosans and alphaalpha-L-arabinofuranosidase: a tool to increase the production of acetic acid. J Appl Microbiol. 2000;88:317–324
  27. MacKenzie DA, Kraunsoe JA, Chesshyre JA. Aberrant processing of wild-type and mutant bovine pancreatic trypsin inhibitor secreted by Aspergillus niger. J Biotechnol. 1998;63:137–146
  28. Ripple GH, Gould MN, Arzoomanian RZ. Phase I clinical and pharmacokinetic study of perillyl alcohol administered four times a day. Clin Cancer Res. 2000;6:390–396
  29. Crowell PL. Prevention and therapy of cancer by dietary monoterpenes. J Nutr. 1999;129:775S–778S
  30. Abu-Elheiga L, Matzuk MM, Abo-Hashema KA, Wakil SJ. Continous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science. 2001;2613–2616
  31. Brudnak MA. Genomic multi-level nutrient-sensing pathways. Med Hypotheses. 2001;56:194–199

PII: S0306-9877(01)91444-6

doi: 10.1054/mehy.2001.1444

Medical Hypotheses
Volume 58, Issue 1 , Pages 28-33 , January 2002