Medical Hypotheses
Volume 58, Issue 3 , Pages 229-231 , March 2002

Can intubation harm the brain in critical care situations? A new simple technique may provide a method for controlling brain temperature

  • N. Einer-Jensen

      Affiliations

    • Department of Physiology and Pharmacology, University of Southern Denmark, Odense, Denmark
  • ,
  • K.E. Baptiste

      Affiliations

    • Danish Veterinary Laboratory, Copenhagen, Denmark
  • ,
  • F. Madsen

      Affiliations

    • Department of Neurosurgery, Copenhagen University Hospital, Copenhagen, Denmark
  • ,
  • M.H. Khorooshi

      Affiliations

    • Department of Physiology and Pharmacology, University of Southern Denmark, Odense, Denmark

Received 9 February 2001 ,Accepted 11 July 2001.

References 

  1. Baker MA. Brain cooling in endotherms in heat and exercise. Annu Rev Physiol. 1982;44:85–96
  2. Bligh J. The thermosensitivity of the hypothalamus and thermoregulation in mammals. Biological Reviews. 1966;41:317–367
  3. Brengelmann G. L. Specialised brain cooling in humans?. FASEB J. 1993;7:1148–1152
  4. Cabanac M. Selective brain cooling in humans: ‘fancy’ or facts?. FASEB J. 1993;7:1143–1146
  5. Caputa M, Kadziela M, Narebski J, Tyczynski M. Brain-cranial venous blood heat exchanger and hypothermia in rabbits. Bulletin de L'Academie Polonaise des Sciences: Serie des Science Biologiques. 1977;25:695–698
  6. Caputa M, Kadziela W, Narebski J. Cerebral temperature regulation in resting and running guinea pigs (Cavia porcellus). Journal of Thermal Biology. 1983;8:265–272
  7. Dietrich W. D. The importance of brain temperature in cerebral injury. J Neurotrauma. 1992;9:475–485
  8. Einer-Jensen N, Svendsen PE, Petersen MB. Decrease in pig brain temperature during nasal flushing and after extubation. Physiological Res. 1999;48:67
  9. Einer-Jensen N, Khorooshi MH. Cooling of the brain through oxygen flushing of the nasal cavities in intubated rats: an alternative model for treatment of brain injury. Exp Brain Res. 2000;130:244–247
  10. Mariak Z, White MD, Lewko J, Lyson T, Piekarski P. Direct cooling of the human brain by heat loss from the upper respiratory tract. J Appl Physiol. 1999;87:1609–1613
  11. Mellergard P, Nordstrom CH. Epidural temperature and possible intracerebral temperature gradients in man. Br J Neurosurg. 1990;4:31–38
  12. Mitchell D, Laburn BP, Nijland MJK, Zurovsky Y, Mitchell G. Selective brain cooling and survival. South African Journal of Science. 1987;83:598–604
  13. Nagasaka T, Brinnel H, Hales JRS, Ogawa T. Selective brain cooling in hyperthermia: the mechanisms and medical implications. Med Hypotheses. 1998;50:203–211
  14. Sternau LL, Thompson C, Dietrich WD, Busto R, Globus MYT, Ginsberg MD. Intracranial temperature observations in the human brain. J Cereb Blood Flow Metab. 1991;8:486–494
  15. Zenker W, Kubik S. Brain cooling in humans: anatomical considerations. Anat Embryol. 1996;193:1–13

PII: S0306-9877(01)91471-9

doi: 10.1054/mehy.2001.1471

Medical Hypotheses
Volume 58, Issue 3 , Pages 229-231 , March 2002