Medical Hypotheses
Volume 58, Issue 2 , Pages 136-140, February 2002

P53 possibly upregulates the expression of CD58 (LFA-3) and CD59 (MIRL)

  • F. Sampaziotis

      Affiliations

    • Department of Histology and Embryology, Medical School, University of Athens, Greece
    • ,
  • S. Kokotas

      Affiliations

    • Department of Histology and Embryology, Medical School, University of Athens, Greece
    • ,
  • V.G. Gorgoulis

      Affiliations

    • Department of Histology and Embryology, Medical School, University of Athens, Greece
    • Molecular Oncology Unit

Received 12 February 2001; accepted 5 July 2001.

Abstract 

P53 is an oncosuppressor protein which acts via transcriptional and non-transcriptional mechanisms. The transcriptional function of p53 is mediated by specific responsive elements (RE). In the present study we found one perfect p53 RE located in the first intron of the gene encoding for CD58 (lymphocyte function Antigen-3/LFA-3) membrane protein. Additionally, we detected one perfect p53 RE within the promoter region and one imperfect p53 RE placed in the first intron of the gene encoding for CD59 (membrane inhibitor of reactive lysis/MIRL). The results of our investigation suggest that p53 may enhance the transcription of both CD59 and CD58 and imply a novel role for p53 as a direct regulator of the immune response.

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  • f1 Correspondence to: Dr V. G. Gorgoulis, 53 Antaiou Str., Lamprini Ano Patissia, Athens, Greece GR-11146. Phone: +3012922143; or +3017796425; Fax: +3012928349; E-mail: histoclub@ath.forthnet.gr

PII: S0306-9877(01)91476-8

doi:10.1054/mehy.2001.1476

Medical Hypotheses
Volume 58, Issue 2 , Pages 136-140, February 2002

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