« Previous
Next »
Medical Hypotheses
Volume 58, Issue 2
, Pages 144-147
, February 2002
A thermodynamic interpretation of malignancy: do the genes come later?
References
- . The clonal evolution of tumor cell populations. Science. 1976;194:23–28
- . The molecular genetics of cancer. Science. 1987;235:305–311
- . Oncogenes and tumor suppressor genes. CA Cancer J Clin. 1994;44:160–170
- . Loss of heterocygosity in fibrocystic change of the breast: genetic relationship between benign proliferative lesions and associated carcinomas. Am J Pathol. 2000;157:323–329
- . Gene regulation networks: a theory of their global structure and behaviours. Curr Top Dev Biol. 1971;6:145–182
-
.
PDP Research Group. Parallel distributing Processing: Explorations in the Microstructures of Cognition. Cambridge: Mass: MIT Press; 1986;
-
.
Applied Reliability. New York: Van Nostrand Reinhold; 1986;
-
.
A two-stage theory of carcinogenesis in relation to the age distribution of human cancer.
Br J Cancer. 1957;9:161–169
-
.
How many mutations are required for tumorigenesis? Implications from human cancer data.
Mol Carcinogen. 1993;17:139–146
- . The origin of oncogenic mutations: where is the primary damage. Carcinogenesis. 2000;21:1773–1776
-
.
Theory of selforganization and evolution: the role of entropy, value and information.
J Non-Equilib Thermodyn. 1992;17:303–308
-
.
Introduction to Thermodynamics of Irreversible Processes. New York: John Wiley; 1962;
-
.
The storage of energy as a cause of malignant transformation: a 7-phase model of carcinogenesis.
Med Hypoth. 1993;41:425–433
- . Heat shock proteins in human cancer. Electrophoresis. 2000;21:1218–1226
-
.
The origin of macromolecular chirality.
Current Biol. 1994;4:758–760
-
.
Physical bioenergetics of degradation-resistant proteins in disease and aging.
Med Hypoth. 1998;51:47–51
- . Chiral selection in poly(C)-directed synthesis of oligo(G). Nature. 1984;310:602–604
- . DNA-like double helix formed by peptide nucleic acid. Nature. 1994;368:561–563
- . Non-enzymatic, post-translational, amino acid modification in ageing: a brief review. Mech Ageing Dev. 1979;10:371–377
- . Amino acid racemization and the preservation of ancient DNA. Science. 1996;272:864–866
- . Role of microglia and host prion protein in neurotoxicity of a prion protein fragment. Nature. 1996;83:345–347
-
.
Aging, genomic entropy and cacinogenesis: implications derived from longitudinal age-specific colon cancer mortality dynamics.
Mech Ageing Devel. 1993;72:165–181
- . DNA repair in relation to ageing processes. J Am Geriatr Soc. 1987;35:532–541
-
.
DNA damage as the primary cause of aging.
Q J Med. 1981;56:279–303
-
.
Earth: Evolution of a Habitable World. Cambridge: Cambridge University Press; 1999;
- . Tetraploidization is a physiological enhancer of wound healing. Eur Surg Res. 1998;30:385–392
- . Genetic instability as the primary cause of human ageing. Exp Gerontol. 1986;21:283–319
-
.
Thermal noice and biological information.
Q J Med. 1987;62:141–152
- . Mutation rates differ among regions of the mammalian genome. Nature. 1989;337:283–285
- . A biochemical mechanism for nonrandom mutations and evolution. J Bacteriol. 2000;182:2993–3001
-
Susko, M. Fragility of Evolution. 2001, submitted to World Futures.
PII: S0306-9877(01)91477-X
doi: 10.1054/mehy.2001.1477
© 2001 Harcourt Publishers Ltd. All rights reserved.
« Previous
Next »
Medical Hypotheses
Volume 58, Issue 2
, Pages 144-147
, February 2002
