Medical Hypotheses
Volume 59, Issue 4 , Pages 367-372 , October 2002

Cell brain crystallization for cancer therapy

  • Q Kong

      Affiliations

    • Cocid Corp, CO, USA
    • Kang-You MedPharm Research Institute, Jinan, China
    • Corresponding Author InformationCorrespondence to: Qingzhong Kong MD, PhD, Cocid Corp, 799 Dahlia St., Denver, CO 80220, USA. Phone: (303)399-4185; Fax: (303)399-4185; Present address: Professor and Director, Cell Brain Research Center, South Biology Building, Room 128, Shandong University, East Campus, Jinan, Shandong Province 250100, China
  • ,
  • J Sun

      Affiliations

    • Cocid Corp, CO, USA
  • ,
  • L.D Kong

      Affiliations

    • Kang-You MedPharm Research Institute, Jinan, China
    • Shandong University 21th Century Research Center, Jinan, China

Received 11 April 2001 ,Accepted 22 November 2001.

References 

  1. Kong Q, Lillehei KO. Antioxidant inhibitors for cancer therapy. Med. Hypotheses. 1998;51:405–409
  2. Kong Q, Beel JA, Lillehei KO. A threshold concept for cancer therapy. Med. Hypotheses. 2000;55:29–35
  3. Venter JC, Adams MD, Myers EW, et al.  Science. 2001;291:1304–1351
  4. Riechmann JL, Heard J, Martin G, et al.  Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science. 2000;290:2105–2110
  5. Richards DE, Peng J, Harberd NP. Plant GRAS and metazoan STATs: one family?. Bioessays. 2000;22:573–577
  6. Nagano Y. Several features of the GT-factor trihelix domain resemble those of the Myb DNA-binding domain. Plant Physiol. 2000;124:491–494
  7. Vision TJ, Brown DG, Tanksley SD. The origins of genomic duplications in Arabidopsis. Science. 2000;290:2114–2117
  8. Web material is available at www.sciencemag.org/cgi/content/full/290/5499/2105/DC1
  9. Lodish H, Baltimore D, Berk A, Zipursky SL, Matsudaira P, Darnell J. In: Molecular cell biology. 3rd ed. New York: W.H. Freeman; 1998;p. 1226
  10. Kirchmaier AL, Rine J. DNA replication-independent silencing in S. cerevisiae. Science. 2001;291:646–650
  11. Laub MT, McAdams HH, Feldblyum T, Fraser CM, Shapiro L. Global analysis of the genetic network controlling a bacterial cell cycle. Science. 2000;290:2144–2148
  12. Li YC, Cheng TH, Gartenberg MR. Establishment of transcriptional silencing in the absence of DNA replication. Science. 2001;291:650–653
  13. Cheng TH, Gartenberg MR. Yeast heterochromatin is a dynamic structure that requires silencers continuously. Genes Dev. 2000;14:452–463
  14. Berset T, Hoier EF, Battu G, Canevascini S, Hajnal A. Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development. Science. 2001;291:1055–1058
  15. Piel M, Nordberg J, Euteneuer U, Bornens M. Centrosome-dependent exit of cytokinesis in animal cells. Science. 2001;291:1550–1553
  16. Bloecher A, Venturi GM, Tatchell K. Anaphase spindle position is monitored by the BUB2 checkpoint. Nat. Cell Biol. 2000;2:556–558
  17. Bardin AJ, Visintin R, Amon A. A mechanism for coupling exit from mitosis to partitioning of the nucleus. Cell. 2000;102:21–31
  18. Pereira G, Hofken T, Grindlay J, Manson C, Schiebel E. The Bub2p spindle checkpoint links nuclear migration with mitotic exit. Mol. Cell. 2000;6:1–10
  19. Hoyt MA. Exit from mitosis: spindle pole power. Cell. 2000;102:267–270 [review]
  20. Rubin GM, Yandell MD, Wortman JR, Gabor Miklos GL, Nelson CR, Hariharan IK, et al.  Comparative genomics of the eukaryotes. Science. 2000;287:2204–2215
  21. Dalgaard JZ, Klar AJ. Orientation of DNA replication establishes mating-type switching pattern in S. pombe. Nature. 1999;400:181–184
  22. Li Y, Breaker RR. Kinetics of RNA degradation by specific base catalysis of transesterification involving the 2-hydroxyl group. J. Am. Chem. Soc. 1999;121:5364–5372
  23. Smith RM, Hansen DE. The pH-rate profile for the hydrolysis of a peptide bond. J. Am. Chem. Soc. 1998;120:8910–8913
  24. Breaker RR. Tech. Sight. Molecular biology. Making catalytic DNAs. Science. 2000;290:2095–2096
  25. Hartman JL, Garvik B, Hartwell L. Principles for the buffering of genetic variation. Science. 2001;291:1001–1004
  26. Scott MP. Development: the natural history of genes. Cell. 2000;100:27–40
  27. Carroll SB. Endless forms: the evolution of gene regulation and morphological diversity. Cell. 2000;101:577–580
  28. Smith JS, Boeke JD. TRANSCRIPTION: Is S phase important for transcriptional silencing?. Science. 2001;291:608–609
  29. Paintrand M, Moudjou M, Delacroix H, Bornens M. Centrosome organization and centriole architecture: their sensitivity to divalent cations. J. Struct. Biol. 1992;108:107–128
  30. Hsu LC, White RL. BRCA1 is associated with the centrosome during mitosis. Proc. Natl. Acad. Sci. USA. 1998;95:12983–12988
  31. Yonekura K, Maki S, Morgan DG, DeRosier DJ, Vonderviszt F, Imada K, et al.  The bacterial flagellar cap as the rotary promoter of flagellin self-assembly. Science. 2000;290:2148–2152
  32. Lingle WL, Lutz WH, Ingle JN, Maihle NJ, Salisbury JL. Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity. Proc. Natl. Acad. Sci. USA. 1998;95:2950–2955
  33. Doxsey S. The centrosome–a tiny organelle with big potential. Nat. Genet. 1998;20:104–106
  34. Hinchcliffe EH, Li C, Thompson EA, Maller JL, Sluder G. Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. Science. 1999;283:851–854
  35. Weber RG, Bridger JM, Benner A, Weisenberger D, Ehemann V, Reifenberger G, et al.  Centrosome amplification as a possible mechanism for numerical chromosome aberrations in cerebral primitive neuroectodermal tumors with TP53 mutations. Cytogenet. Cell Genet. 1998;83:266–269
  36. Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, et al.  Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat. Genet. 1998;20:189–193
  37. Lodish H, Baltimore D, Berk A, Zipursky SL, Matsudaira P, Darnell J. In: Molecular Cell Biology. 3rd ed. New York: W.H. Freeman; 1998;p. 1242
  38. Hinchcliffe EH, Miller FJ, Cham M, Khodjakov A, Sluder G. Requirement of a centrosomal activity for cell cycle progression through G1 into S phase. Science. 2001;291:1547–1550
  39. Szuromi P. Centrosomes center stage. THIS WEEK IN SCIENCE. Science. 2001;291:1443–1445
  40. Mansur NR, Meyer-Siegler K, Wurzer JC, Sirover MA. Cell cycle regulation of the glyceraldehyde-3-phosphate dehydrogenase/uracil DNA glycosylase gene in normal human cells. Nucleic Acids Res. 1993;21:993–998
  41. Chen FW, Ioannou YA. Ribosomal proteins in cell proliferation and apoptosis. Int. Rev. Immunol. 1999;18:429–448
  42. Fry AM, Arnaud L, Nigg EA. Activity of the human centrosomal kinase, Nek2, depends on an unusual leucine zipper dimerization motif. J. Biol. Chem. 1999;274:1304–1310
  43. Keryer G, Skalhegg BS, Landmark BF, Hansson V, Jahnsen T, Tasken K. Differential localization of protein kinase A type II isozymes in the Golgi-centrosomal area. Exp. Cell Res. 1999;249:131–146
  44. Bakkenist CJ, Koreth J, Williams CS, Hunt NC, McGee JO. Heat shock cognate 70 mutations in sporadic breast carcinoma. Cancer Res. 1999;59:4219–4221
  45. Nakadai T, Kishimoto T, Miyazawa Y, Okada N, Makino Y, Obinata T, et al.  HP33: hepatocellular carcinoma-enriched 33-kDa protein with similarity to mitochondrial N-acyltransferase but localized in a microtubule-dependent manner at the centrosome. J. Cell Sci. 1999;112:1353–1364
  46. Kimura M, Matsuda Y, Yoshioka T, Okano Y. Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3. J. Biol. Chem. 1999;274:7334–7340
  47. Gstaiger M, Marti A, Krek W. Association of human SCF(SKP2) subunit p19(SKP1) with interphase centrosomes and mitotic spindle poles. Exp. Cell Res. 1999;247:554–562
  48. Mussman JG, Horn HF, Carroll PE, Okuda M, Tarapore P, Donehower LA, et al.  Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression. Oncogene. 2000;19:1635–1646
  49. Carroll PE, Okuda M, Horn HF, Biddinger P, Stambrook PJ, Gleich LL, et al.  Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression. Oncogene. 1999;18:1935–1944

PII: S0306-9877(02)00109-3

Medical Hypotheses
Volume 59, Issue 4 , Pages 367-372 , October 2002