Medical Hypotheses
Volume 59, Issue 4 , Pages 389-397 , October 2002

Osteoarthritis as an inevitable consequence of the structure of articular cartilage

  • Ken Muldrew

      Affiliations

    • Corresponding Author InformationCorrespondence to: Ken Muldrew PhD, Joint Injury and Arthritis Research Group, 3330 Hospital Dr. NW, Calgary, AB T2N4N1, Canada. Phone: 403-220-5976; Fax: +403-270-0617

Received 18 June 2001 ,Accepted 1 November 2001.

References 

  1. Buckwalter JA, Mankin HJ. Articular cartilage II. Degeneration and osteoarthrosis, repair, regeneration, and transplantation. J. Bone Joint Surg. 1997;79A:612–632
  2. Fragonas E, Pollesello P, Mlinarik V, Toffanin R, Grando C, Godeas C, et al.  Sensitivity of chondrocytes of growing cartilage to reactive oxygen species. Biochim. Biophys. Acta. 1998;1425:103–111
  3. Tiku ML, Gupta S, Deshmukh DR. Aggrecan degradation in chondrocytes is mediated by reactive oxygen species and protected by antioxidants. Free Radical Research. 1999;30:395–405
  4. Tiku ML, Shah R, Allison GT. Evidence linking chondrocyte lipid peroxidation to cartilage matrix protein degradation. Possible role in cartilage aging and the pathogenesis of osteoarthritis. J. Biol. Chem. 2000;275:20069–20076
  5. Buckwalter JA, Mankin HJ. Articular cartilage: tissue design and chondrocyte-matrix interactions. Instr. Course Lect. 1998;47:477–486
  6. Hirotani H, Ito T. Chondrocyte mitosis in the articular cartilage of femoral heads with various diseases. Acta Orthop. Scand. 1975;46:979–986
  7. Hulth A, Lindberg L, Telhag H. Mitosis in human osteoarthritic cartilage. Clin. Orthop. Rel. Res. 1972;84:197–199
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  9. Rothwell A, Bentley G. Chondrocyte multiplication in osteoarthritic articular cartilage. J. Bone Joint Surg. 1973;556:588–594
  10. Crelin ES, Southwick WO. Mitosis of chondrocytes induced in the knee joint articular cartilage of adult rabbits. Yale J. Biol. Med. 1960;33:243–244
  11. Trias A. Effect of persistent pressure on the articular cartilage. J. Bone Joint Surg. 1961;43B(2):376–386
  12. Muldrew K, Chung M, Novak K, Schachar NS, Rattner JB, Matyas J. Chondrocyte regeneration in adult ovine articular cartilage following cryoinjury and long-term transplantation. Osteoarthritis and Cartilage. 2001;9:432–439
  13. Brandt KD. Transection of the anterior cruciate ligament in the dog: a model of osteoarthritis. Semin Arthritis Rheum. 1991;21:22–32
  14. Adams ME, Grant MD, Ho A. Cartilage proteoglycan changes in experimental canine osteoarthritis. J. Rheumatol. 1987;14(Spec No):107–109
  15. Adams ME, Brandt KD. Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection. J. Rheumatol. 1991;183:428–435
  16. Finsterbrush A, Friedman B. Reversibility of joint changes produced by immobilization in rabbits. Clin. Orthop. 1975;111:290–298
  17. Palmoski MJ, Colyer RA, Brandt KD. Joint Motion in the absence of normal loading does not maintain normal articular cartilage. Arthritis. Rheum. 1980;23:325–334
  18. Hurtig M, Novak K, McPherson R, McFadden S, McGann LE, Muldrew K, et al.  Osteochondral dowel transplantation for the repair of focal defects in the knee: an outcome study using an ovine model. Vet. Surg. 1998;27:5–16
  19. Okada Y, Sakakida K, Fujita T, Mizutani A. Experimental studies on half-joint transplantation. Antigenicity of fresh allografted articular cartilage and changes in the articular cartilage. Int. Orthop. 1990;14:261–267

PII: S0306-9877(02)00122-6

Medical Hypotheses
Volume 59, Issue 4 , Pages 389-397 , October 2002

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