Medical Hypotheses
Volume 59, Issue 4 , Pages 411-415 , October 2002

Rheumatoid arthritis is auto-immunoreaction to collagen II in cartilage happened in synovial tissue

  • Jicun Wang
    • ,
  • Xinping Liu
    • ,
  • Fuyang Li
    • ,
  • Libo Yao

      Affiliations

    • Corresponding Author InformationCorrespondence to: Libo Yao PhD, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, 710032 Shaanxi, China. Phone: 086-029-3374514; Fax: 086-029-3234516

Received 3 September 2001 ,Accepted 20 December 2001.

References 

  1. Courtenay JS, Dallman MJ, Dayan AD, Martin A, Mosedale B. Immunization against heterologous type II collagen induces arthritis in mice. Nature. 1980;283(5748):666–668
  2. Cook AD, Rowley MJ, Stockman A, Muirden KD, Mackay IR. Specificity of antibodies to type II collagen in early rheumatoid arthritis. J. Rheumatol. 1994;21(7):1186–1191
  3. Ratkay LG, Tait B, Tonzetich J, Waterfield JD. Lpr and MRL background gene involvement in the control of adjuvant enhanced arthritis in MRL-lpr mice. J. Autoimmun. 1994;7(5):561–573
  4. Thomas R, Davis LS, Lipsky PE. Rheumatoid synovium is enriched in mature antigen-presenting dendritic cells. J. Immunol. 1994;152(5):2613–2623
  5. Wang JC, Yao LB, Lü HS, Liu XP, Deng YC, Sun TZ, et al. Expression analysis of protein tyrosine kinases in fibroblast-Iike synovial cells of rheumatoid arthritis. Med. J. Chin. Liberation Army (Chinese Journal). 2001;26:82–84
  6. Vogel W, Gish GD, Alves F, Pawson T. The discoidin domain receptor tyrosine kinases are activated by collagen. Mol. Cell. 1997;1(1):13–23
  7. Enjoji M, Kotoh K, Iwamoto H, Nakamuta M, Nawata H. Self-regulation of type I collagen degradation by collagen-induced production of matrix metalloproteinase-1 on cholangiocarcinoma and hepatocellular carcinoma cells. In Vitro Cell. Dev. Biol. Anim. 2000;36(2):71–73
  8. Evans CH, Ghivizzani SC, Kang R, et al.  Gene therapy for rheumatic diseases. Arthritis Rheum. 1999;42(1):10–16
  9. Okada Y, Nagase H, Harris ED. Matrix metalloproteinases 1, 2, and 3 from rheumatoid synovial cells are sufficient to destroy joints. J. Rheumatol. 1987;14:41–42
  10. Unemori EN, Hibbs MS, Amento EP. Constitutive expression of a 92-kD gelatinase (type V collagenase) by rheumatoid synovial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines. J. Clin. Invest. 1991;88(5):1656–1662
  11. Muller-Ladner U, Kriegsmann J, Franklin BN, Matsumoto S, Geiler T, Gay RE, et al. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am. J. Pathol. 1996;149(5):1607–1615

PII: S0306-9877(02)00143-3

Medical Hypotheses
Volume 59, Issue 4 , Pages 411-415 , October 2002

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