Medical Hypotheses
Volume 59, Issue 4 , Pages 429-432 , October 2002

Lithium and antidepressants: inhibiting eicosanoids, stimulating immunity, and defeating microorganisms

  • Julian Lieb

      Affiliations

    • Corresponding Author InformationCorrespondence to: Julian Lieb MD, 22 Rimmon Road, Woodbridge, Conn 06525, USA. Phone: +1-203-397-1226; Fax: +1-203-397-1246

Received 19 December 2001 ,Accepted 13 February 2002.

References 

  1. Lieb J. Remission of recurrent herpes infection during therapy with lithium. N. Engl. J. Med. 1979;301(17):942
  2. Lieb J. Remission of herpes virus infection and immunopentiation with lithium carbonate: inhibition of prostaglandin E1 synthesis by lithium may explain its antiviral, immunopotentiating, and antimanic properties. Biol. Psychiatry. 1981;695–698
  3. Amsterdam J, Maislin G, Rybakowski J. A possible antiviral action of lithium carbonate in herpes simplex virus infections. Biol. Psychiatry. 1990;27:447–453
  4. Amsterdam J, Maislin G, Potter L, et al.  Suppression of recurrent genital herpes infections with lithium carbonate: a randomized, placebo-controlled trial. Lithium. 1991;2:17–25
  5. Shenkman L, Borkowsky W, Holzman R, et al.  Enhancement of lymphocyte and macrophage function in vitro by lithium chloride. Clin. Immunol. 1978;10:187–192
  6. Shenkman L, Borkowsky W, Shopsin B. Lithium as an immunologic adjuvant. Med. Hypotheses. 1980;6:1–6
  7. Weetman A, McGregor A, Lazarua J, et al.  The enhancement of immunoglobulin synthesis by human lymphocytes with lithium. Clin. Immunol. 1982;22:400–407
  8. Hansell N. Manic illness presenting with physical symptoms. Am. J. Psychiatry. 1990;147(11):1575
  9. Skinner G, Hartley C, Buchan A, et al.  The effect of lithium chloride on the replication of herpes simplex virus. Med. Microbiol. Immunol. 1980;168:139–148
  10. Rosenthal S. Does phenelzine relieve apththous ulcers of the mouth?. N. Engl. J. Med. 1984;442
  11. Lieb J. Remission of rheumatoid arthritis and other disorders of immunity in patients taking monoamine oxidase inhibitors. Int. J. Immunopharmacol. 1983;5(4):353–357
  12. Rosenthal S, Fitch W. The antiherpetic effects of phenelzine. J. Clin. Psychopharmacol. 1987;7(2):119
  13. Yeragani V, Phol R, Keshavan M, et al.  Are tricyclic antidepressants effective for aphthous ulcers?. J. Clin. Psychiatry. 1987;48(6):256
  14. Lofft J. MAO inhibitors. Psychiatry Times. 1985;(November):
  15. Lancet Editorial (353) 1999; I: 1636
  16. Zilberstein D, Dwyer D. Antidepressants cause lethal disruption of membrane function in the human protozoan parasite Leishmania. Science. 1984;226:977
  17. Weinbach E, Costa J, Wieder S. Antidepressants drugs suppress growth of the human pathogenic protozoan giardia lamblia. Res. Commun. Chem. Pathol. Pharm. 1985;47(1):145–148
  18. Bitionti A, Sjoerdsma A, McCann P, et al.  Reversal of chloroquine resistance in malaria parasite plasmodium falciparum by desipramine. Science. 1988;242(48883):1301–1303
  19. Salama A, Facer C. Desipramine reversal of chloroquine resistance in wild isolates of Plasmodium falciparum. Lancet. 1990;335:164–165
  20. Reite M, Harbeck R, Hoffman A. Altered cellular immune response following peer separation. Life Sci. 1981;29(11):1133–1136
  21. Kronfol Z, Silva J, Greden J, et al.  Impaired lymphocyte function in depressive illness. Life Sci. 1983;33:241–247
  22. Kronfol Z, Turner R, Nasrallah H, et al.  Leukocyte regulation in depression and schizophrenia. Psychiatry Res. 1984;13:13–18
  23. Calabrese J, Gulledge A. Prostaglandin E2 and depression. Biol. Psychiatry. 1984;9(8):1269–1270
  24. Calabrese J, Skwerer R, Barna B, et al.  Depression immunocompetence and prostaglandins of the E series. Psychiatry Res. 1984;17:41–47
  25. Evans DL, Pedersen CA, Folds JD. Major depression and immunity: preliminary evidence of decreased natural killer cell populations. Prog. Neurol.–Psychopharmacol. Biol. Psychiatry. 1988;12:739–748
  26. Frank M, Hendricks S, Johnson D, et al.  Antidepressants augment natural killer cell activity: in vivo and in vitro. Neuropsychobiology. 1999;39(1):18–24
  27. Baker P, Fahey J, Munck A. Prostaglandin inhibition of T-cell proliferation is mediated at two levels. Cell. Immunol. 1981;61:52–61
  28. Bankhurst A. The modulation of human natural killer cell activity by prostaglandins. J. Clin. Lab. Immunol. 1982;7:8591
  29. Fulton A, Levy J. The possible role of prostaglandins in mediating immune suppression by nonspecific T suppressor cells. Cell Immunol. 1980;52:29–37
  30. Fulton A, Levy J. The induction of nonspecific T suppressor lymphocytes by prostaglandin E1. Cell Immunol. 1981;59:54–60
  31. Goodwin J. Prostaglandin synthetase inhibitors as immunoadjuvants in the treatment of cancer. J. Immunopharmacol. 1981;59:54–60
  32. Goodwin J, Ceuppens J. Regulation of the immune response by prostaglandins. Clin. Immunol. Immunopathol. 1980;15:106–122
  33. Angeli V, Faveeuw C, Roye O, et al.  Role of the parasite-derived prostaglandin D2 in the inhibition of epidermal Langerhans cell migration during schistosomiasis infection. J. Exp. Med. 2001;10:1135–1147
  34. Farrell J, Kirkpatrick C. Experimental cutaneous leishmaniasis II. A possible role for prostaglandins in exacerbation of disease in leishmania major-infected BALB/c mice. J. Immunol. 1987;138(3):902–907
  35. Kubata B, Eguchi N, Urade Y, et al.  Plasmodium falciparum produces prostaglandins that are pyrogenic, somnogenic, and immunosuppressive substances in humans. J. Exp. Med. 1998;188(6):1197–1202
  36. Noverr M, Phare S, Toews G, et al.  Pathogenic yeasts Cryptococcus neoformans and Candida albicans produce immunomodulatory prostaglandins. Infect. Immunol. May, 2001;69(5):2957–2963
  37. Sawaoka H, Kawano S, Tsuji S, et al.  Helicobacter pylori infection induces cyclooxygenase-2 in human gastric mucosa. Prostaglandins Leukot. Essent. Fatty Acids. 1998;59(5):313–316
  38. Lieb J. Eicosanoids: molecules of evolution. Med. Hypotheses. 2001;56(6):686–693
  39. Horrobin D, Mtabaji J, Manku M, et al.  Lithium as a regulator of hormone-stimulated prostaglandin synthesis. In: Lithium in Medical Practice Baltimore. Baltimore, MD: University Park Press; 1978;p. 243–263
  40. Wang Y, Pandey G, Mendels J, et al.  Effect of lithium on prostaglandin El stimulated adenylate cyclase activity of human platelets. Biochem. Pharmacol. 1974;23:245–255
  41. Murphy D, Donnelly C, Moskowitz J. Inhibition by lithium of prostaglandin El and norepinephrine effects on cyclic adenosine monophosphate production in human platelets. Clin. Pharmacol. Ther. 1973;14(5):810–814
  42. Reches A, Benalal D, Weissman B, et al.  Inhibition by lithium of prostaglandin El-sensitive adenylate cyclase in neuroblastoma × glioma hybrid cells: approach to the attenuation of the opiate withdrawal syndrome. Clin. Neuropharmacol. 1982;5(4):395–404
  43. Chang M, Grange E, Rabin O, et al.  Lithium decreases turnover of arachidonate in several brain phosholipids. Neurosci. Lett. 1996;220:171–174
  44. Chang M, Jones C. Chronic lithium treatment decreases brain phospholipase A (2) activity. Neurochem. Res. 1998;23:887–892
  45. Lee R. The influence of psychotropic drugs on prostaglandin biosynthesis. Prostaglandins. 1974;5(1):63–68
  46. Ellis E, Rosenblum W, Birkle D, et al.  Lowering the brain levels of the depressant prostaglandin D2 by the antidepressant tranylcypromine. Biochem. Pharmacol. 1982;31(9):1783–1784
  47. Hong S, Carty T, Deykin D. Tranylcypromine and 15-hydroperoxyarachidonate affect arachidonic acid release in addition to inhibition of prostacyclin synthesis in calf aortic endothelial cells. J. Biol. Chem. 1983;225(20):9538–9540
  48. Janicke U, Forster W. Effects of imipramine, chlorpromazine and promazine pretreatment on the in vitro prostaglandin biosynthesis of rabbit brain and renal medulla. Pharmacol. Res. Commun. 1977;9(5):501–507
  49. Mak O, Chen S. Effects of two antidepressant drugs imipramine and amitriptyline on the enzyme activity of 15-hydroxyprostaglandin dehydrogenase purified from brain, lung, liver and kidney of mouse. Prog. Lipid Res. 1986;25:153–155
  50. Leung K, Mihich E. Prostaglandin modulation of development of cell-mediated immunity in culture. Nature. 1980;288:597–600
  51. Cherkasova TD, Shepelava GK, Shalygina NB, et al.  The prostaglandin and cyclic nucleotide levels in the organs of mice with experimental anthrax intoxication. Zh. Mikrobio. Epidemiol. Immununobiol. 1991;3:70–73

PII: S0306-9877(02)00148-2

Medical Hypotheses
Volume 59, Issue 4 , Pages 429-432 , October 2002