« Previous
Next »
Medical Hypotheses
Volume 59, Issue 3
, Pages 302-311
, September 2002
Does the pineal gland have a role in the psychological mechanisms involved in the progression of cancer?
References
- . Stress and cancer: the state of the art. Psychosomatics. 1980;21(part 1):975–981
- . Emotions as a cause of cancer:18th and 19th century contributions. Psychoanal. Rev. 1955;42:217–227
-
Evans E. A Psychological Study of Cancer. New York, Dodd: Mead, 1926
-
.
The respective importance of personality, cigarette smoking and interaction effects for the genesis of cancer and heart disease.
Person. Individ. Diff. 1988;9:453–464
-
.
Denial and repression of primitive impulses and of disturbing emotions in patients with malignant neoplasms.
In:
Kissen DM, LeShan L editor. Psychosomatic Aspects of Neoplastic Disease. Philadelphia: Lippincott; 1964;p. 42–62
- . Personality as a risk factor in large bowel cancer. Data from the Melbourne Colorectal Cancer study. Psychol. Med. 1991;21:29–41
- . Life change and gastric cancer. Psychosom. Med. 1980;42:499–502
- . Psychosocial risk factors in lung cancer. Psychosom. Med. 1979;41:503–514
- . Psychosomatic factors in breast cancer patients. Results of a case control study. J. Psychosom. Obstet. Gynaecol. 1986;5:127–136
- . Recent life changes and large bowel cancer. Data from the Melbourne Colorectal Cancer study. J. Clin. Epidemiol. 1991;44:57–68
-
.
Stress.
In:
Donovan BT editors. Humours, Hormones and the Mind. Stockton Press: Year Book Medical Publishers; 1988;p. 172–184
- . Perceived religiousness is protective for colorectal cancer: Data from the Melbourne Colorectal cancer study. J. R. Soc. Med. 1993;86:645–647
-
.
The Psyche and the development of malignant disease.
In:
Kune GA, Bannerman S editor. The Psyche and Cancer. Melbourne: University of Melbourne Press; 1992;p. 11–14
-
.
Stress, Hormone Responses, and Cancer.
In:
Tache J, Selye H, Day SB editor. Cancer Stress and Death. New York, London: Plenum Book Company; 1979;p. 29–41
-
.
Psychosomatics in cancer.
In:
Guex P editors. An Introduction to Psycho-oncology. London, New York: Routledge; 1989;p. 1–10
- . Social stress influences tumour growth. Psychosom. Med. 1980;42(3):347–365
-
.
Effect of brightness or darkness on carcinogenesis.
J. Nagoya City Univ. Med. Assoc. 1968;19:525–557
-
.
In: Brain and Behaviour. Momterey, California: Brooks/Love Publishing Company; 1977;p. 146
- . Effect of partial hippocampal resection on stress mechanism in rats. Am. J. Physiol. 1961;201(2):337–340
-
.
Ciba foundation symposium.
In: Melatonin and the Pineal. Circadian Rhythms and Photoperiodism. London: Churchill Livingstone; 1985;p. 117
-
.
The pineal gland and melatonin in affective disorders.
In:
Brown GM, Wainwright SD editor. The Pineal Gland: Endocrine Aspects. Oxford, New York, Toronto: Pergamon Press; 1985;p. 313–325
- . Plasma melatonin levels in depression. Aust. N. Z. J. Psychiatry. 1986;20:381–383
- . Melatonin and N-Acetylserotonin stress responses:Effect of type of stimulation and housing conditions. J. Pineal Res. 1985;2:39–49
-
.
Pineal actions on the autonomic system.
Pineal Res. Rev. 1987;5:217–263
-
.
Role of melatonin in health and disease.
Clin. Endocrinol. 1995;42:221–234
- . Stress as a medical and scientific idea and its implications. Adv. Pharmacol. 1998;42:552–556
- . Coping with stress: parallelism between the effects of septal lesions on growth hormone and corticosterone levels. Biol. Psychiatry. 1976;11:583–597
-
.
Effect of psychic stress of examination on serum growth hormone, serum insulin and plasma renin activity.
Acta. Pharmacol. Toxicol. 1976;38:344–352
-
.
Role of hypothalamus in mediating stress effects on the immune system.
In:
Stoll BA editors. Mind and Cancer Prognosis. Chichester, New York: John Wiley; 1979;p. 86–101
- . Growth of Yoshida ascites tumour in the rat after radiofrequency destruction of the tuberoinfundibular region of the hypothallamus. Neuroendocrinology. 1980;30:88–93
-
.
Labelling index of L 1210 and Ehrlich ascites tumour cells after radiofrequency destruction of the tuberoinfundibular region of the hypothalamus in the mouse.
Neuroendocrinol. Lett. 1981;3:347–354
- Increased tumour cell multiplication after radiofrequency lesions in the median hypothalamus in the mouse and rat. Neuroendocrinology. 1986;42:407–415
-
.
A comparison of cell proliferation in normal and neoplastic intestinal epithelia following either biogenic amine depletion or monoamine oxidase inhibition.
Virchows Arch. B. 1976;21:161–168
- . Melatonin receptors in the rat brain and pituitary. J. Pineal Res. 1995;19:173–177
- . Regional uptake of 3 H-melatonin from blood or cerebrospinal fluid by rat brain. Nature. 1969;221:474–475
-
.
Melatonin: origin control of circadian rhythm and site of action.
In:
Birau N, Schloot W editor. Current Status and Perspectives.
Advances in the Biosciences. Vol. 29:Oxford, New York: Pergamon Press; 1981;p. 193–196
- . Differential effects of pinealectomy on amygdala and hippocampus serotonin metabolism. J. Pineal Res. 1991;10:100–103
- . Evidence for a nervous connection between the brain and the pineal organ in the guinea pig. Cell Tissue Res. 1980;209:505–510
- . The mammalian pineal gland and its control of hypothalamic activity. Prog. Brain Res. 1974;41:149–174
-
.
Selective mechanisms in hormonal therapy.
In:
Stoll BA editors.
Secondary Spread in Breast Cancer. Vol. 3:London: Heinemann Medical; 1977;p. 169–171
- . Circadian rhythm of melatonin, corticosterone and phagocytosis: effect of stress. J. Pineal Res. 2001;30:180–187
-
.
An effect of pinealectomy on rat small intestinal crypt cell kinetics.
IRCS Med. Sci. 1978;6:540
-
.
The effect of bilateral amygdaloid nucleus lesions on rat small bowel crypt cell kinetics.
Virchows Arch. B. 1989;57:231–236
-
.
The effect of bilateral hippocampal lesions and autonomic denervation of the small bowel on rat crypt cell kinetics.
Med. Sci. Res. 1989;17:825–826
- . Effect of septal and fornix lesions on rat small bowel crypt cell kinetics. Digestion. 1990;45:34–39
- . Increased cell division as a cause of human cancer. Cancer Res. 1990;50:7415–7421
-
.
Is the limbic system a system? Studies of hippocampal efferents: their functional and clinical applications.
In:
Doane BK, Livingston KE editor. The Limbic System: Functional Organization and Clinical Disorders. New York: Raven Press; 1986;p. 79–84
- . The modulation of neuronal activity by melatonin: in vitro studies on mouse hippocampal slices. J. Pineal Res. 2001;30:87–96
- . Melatonin inhibition and pinealectomy enhancement of 7,12- 7,12- 7,12-dimethylbenzantracene-induced mammary tumours in the rat. Cancer Res. 1981;41:4432–4436
- . Effect of melatonin on experimental tumours under different photoperiods and times of administration. J. Neural Transm. 1981;52:269–279
- . Effect of B16 melatonin on melanoma growth in athymic mice. Cancer Res. 1985;45:4175–4177
-
.
The oncostatic and oncomodulatory role of the pineal gland and melatonin.
Adv. Pineal Res. 1994;7:235–241
-
.
Diminished pineal function coincides with disturbed circadian endocrine rhythmicity in untreated primary cancer patients. Consequence of premature aging or of tumour growth?.
Ann. N.Y. Acad. Sci. 1994;719:502–525
- Nocturnal urinary 6-sulphatoxymelatonin and proliferating cell nuclear antigen-immunopositive tumour cells show strong positive correlations in patients with gastrointestinal and lung cancer. J. Pineal Res. 1997;23:90–96
- . Melatonin modulates growth factor activity in MCF-7 human breast cancer cells. J. Pineal Res. 1994;17:25–32
- . Influence of melatonin on the proliferation of hepatoma cells in the Syrian hamster: in vivo and in vitro study. J. Pineal Res. 1992;13:107–110
- . The clinical neuroimmunotherapeutic role of melatonin in oncology. J. Pineal Res. 1995;19:103–110
- . Effects of melatonin on microtubule assembly depend on hormone concentration: role of melatonin as a calmodulin antagonist. J. Pineal Res. 1994;17:55–62
- . Plasma melatonin levels in patients suffering from colorectal carcinoma. J. Pineal Res. 1988;5:251–258
-
.
Serum melatonin circadian profile in women with adenocarcinoma of uterine corpus.
Int. J. Thymol. 1996;4(suppl. 1):80–83
-
.
Antiproliferative effects of melatonin and CGP 52608 on the murine Colon 38 adenocarcinoma in vitro and in vivo.
Neuroendocrinol. Lett. 1998;19:71–78
-
.
Melatonin and colon carcinogenesis.
In:
Bartsch C, Bartsch H, Blask DE, Cardinali DP, Hrushesky WJM, Mecke D editor. The Pineal Gland and Cancer. Berlin, Heidelberg, New York: Springer-Verlag; 2001;p. 241–258
- . Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesions in the rat. Gastroenterology. 1985;88:1162–1167
- . Potential molecular mechanisms of oxidant-induced carcinogenesis. Environ. Health Perspect. 1994;102(suppl. 10):155–157
- The oxidant/antioxidant network: role of melatonin. Biol. Signals Recept. 1999;8:56–63
- . The validity of melatonin as an oncostatic agent. J. Pineal Res. 1997;22:184–202
- . The human pineal gland:a review of the `third eye' and the effect of light. Aust. N. Z. J. Ophthalmol. 1987;15:329–336
- . Melatonin receptors in the rat brain and pituitary. J. Pineal Res. 1995;19:173–177
- . Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr. Rev. 1991;12:151–180
- . Melatonin modulation of estrogen-regulated proteins, growth factors, and proto-oncogenes in human breast cancer. J. Pineal Res. 1995;18:93–103
-
.
Melatonin and cancer treatment.
In:
Watson RR editors. Melatonin in the Promotion of Health. Boca Raton, London, New York: CRC Press; 1999;p. 175–189
-
Environmental and heritable factors in the causation of cancer.
N. Eng. J. Med. 2000;343:78–85
- Modulation of interleukin-2-induced macrophage activation in cancer patients by the pineal hormone melatonin. J. Biol. Regul. Homeost. Agents. 1991;5:154–156
- . The immunoendocrine role of melatonin. J. Pineal Res. 1993;14:1–10
- . Stress and cancer: the state of the art. Part 2. Psychosomatics. 1981;22:207–220
- . Hypothalamic-immune interactions; 1-the acute effect of anterior hypothalamic lesions on the immune response. Brain Res. 1980;196:79–87
- . Neuroimmunomodulation: neuroanatomical basis for impairment and facilitation. Ann. Neurol. 1982;12:56–61
-
.
Stress and pathology: immunological and central nervous system interactions.
In:
Cooper CL editors. Psychosocial Stress in Cancer. Chichester: John Wiley; 1984;p. 93–147
-
.
Modulation of natural killer cell activity by life stress and coping ability.
In:
Levy SM editors. Biological Mediators of Behaviour and Disease: Neoplasia. New York: Elsevier Biomedical; 1982;p. 3–28
- . Suppression of lymphocyte stimulation following bereavement. JAMA. 1983;250:374–377
- . Suppresssion of immunity by stress: effects of a graded series of stressors on lymphocyte stimulation in the rat. Science. 1981;213:1397–1400
- Cell protective role of melatonin in the brain. J. Pineal Res. 1995;19:57–63
-
.
Will to live and survival time in cancer.
In:
Stoll BA editors. Prolonged Arrest of Cancer. Chichester: John Wiley; 1982;p. 117–134
- . Medical response to mental stress. J. R. Soc. Med. 1994;87:536–539
-
.
Effect of psychosocial treatment on survival of patients with metastatic breast cancer.
Lancet. 1989;ii:888–891
- . Psychological response to breast cancer and 15 year outcome. Lancet. 1990;335:49–50
-
.
Melatonin: that ubiquitously acting pineal hormone.
News Physiol. Sci. 1991;6:223–227
-
.
The role of the pineal gland in neural control of cell proliferation in healthy and malignant tissue.
In:
Bartsch C, Bartsch H, Hrushesky WJM, Blask DE, Cardinali DP, Mecke D editor. The Pineal Gland and Cancer. Berlin, Heidelberg, New York: Springer; 2001;p. 417–441
-
.
Neoplasia of the gastrointestinal tract.
In:
Henderson JM editors. Gastrointestinal pathophysiology. Philadelphia: Lippincott-Raven; 1996;p. 235–261
- . Colorectal cancer: surgical prophylaxis and chemoprevention. Ann. R. Coll. Surg. Engl. 1995;77:372–376
- . Mutations in the p 53 tumour suppressor gene in human cutaneous squamous cell carcinomas. Mol. Carcinog. 1991;4:445–449
- . DNA repair rates mapped along the human PGK 1 gene at nucleotide resolution. Science. 1994;263:1438–1440
-
.
Effect of melatonin cis-platinum induced genetic damage to the bone marrow cells of mice.
Med. Sci. Res. 1992;20:179–180
- . Regression of cancer after intensive meditation (preliminary report). Med. J. Aust. 1976;2:184
- . Growth and new growth: environmental carcinogens in the process of human ontogeny. Prog. Clin. Cancer. 1970;4:1–29
- A randomised study with subcutaneous low dose interleukin-2 alone vs interleukin-2 plus the pineal neurohormone melatonin in advanced solid neoplasm other than renal cancer and melanoma. Br. J. Cancer. 1994;69:196–199
PII: S0306-9877(02)00173-1
« Previous
Next »
Medical Hypotheses
Volume 59, Issue 3
, Pages 302-311
, September 2002
