Immunological mechanisms of adaptation to the low-weight chemical compounds in ontogenesis

Abstract 

It is postulated that adaptation to the low-weight chemical compounds includes six consistent ontogenetic periods: the reciprocal selection of the marriage partners; the maturation of the gametes; the formation of the zygote; the development of the fetus; the birth and nursing of the child; and the sexual maturation of a human being. The main immunological parts of adaptation are: the antibodies to the low-weight xeno- and endobiotics; the reciprocal immune-like recognition of the maternal and paternal gametes; and the maternal immune reaction on the paternal histocompatibility antigens of the fetus. The main immunological mechanisms of adaptation are: the promotion of the selectivity in the smell recognition of the marriage partners by the antibodies to the xeno- and endobiotics expanding the individual spectrum of their metabolites; the inhibition of the xenobiotic genotoxic action on the gametes, fetus and child by the antibodies; the prevention of the development of gene-damaged gametes and fetus by antibodies to the sexual hormones; and the immune preservation (elimination) of the heterozygote (homozygote) fetus.