Medical Hypotheses
Volume 62, Issue 1 , Pages 79-81, January 2004

Portal hypertension: return to fetal life to re-attempt differentiation?

  • M.A. Aller

      Affiliations

    • Surgery Chair, Surgery Department I, School of Medicine, Complutense University of Madrid, Spain
    • ,
  • L. López

      Affiliations

    • Psychobiology Laboratory, School of Psychology, University of Oviedo, Spain
    • ,
  • M.P. Nava

      Affiliations

    • Animal Physiology II Department, School of Biological Sciences, Complutense University of Madrid, Spain
    • ,
  • J.L. Arias

      Affiliations

    • Psychobiology Laboratory, School of Psychology, University of Oviedo, Spain
    • ,
  • H.J. Durán

      Affiliations

    • Surgery Chair, Surgery Department I, School of Medicine, Complutense University of Madrid, Spain
    • ,
  • J. Arias

      Affiliations

    • Surgery Chair, Surgery Department I, School of Medicine, Complutense University of Madrid, Spain
    • Corresponding Author InformationCorresponding author. Tel.: +34-91-3941388; fax: +34-91-3947115

Received 13 December 2002; accepted 30 July 2003.

Abstract 

We speculate on the final meaning of the alterations that characterize portal hypertensive enteropathy.

The similarity of these alterations with certain morphofunctional characteristics of prenatal splanchnic development makes it possible to hypothesize that the dedifferentiation with return to early stages of development could constitute a portal hypertension induced pathogenic mechanism.

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PII: S0306-9877(03)00275-5

doi:10.1016/S0306-9877(03)00275-5

Medical Hypotheses
Volume 62, Issue 1 , Pages 79-81, January 2004

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