Principles of magnetodynamic chemotherapy

Babincová, M.; Leszczynska, D.; Sourivong, P.; Babinec, P.; Leszczynski, J.

doi:10.1016/j.mehy.2003.10.003

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Volume 62, Issue 3 , Pages 375-377, March 2004

Principles of magnetodynamic chemotherapy

M. Babincová
- Department of Biophysics and Chemical Physics, Comenius University, Mlynska dolina F1, Bratislava 842 48, Slovakia
- Corresponding author. Tel.: +421-2-6029-5685; fax: +421-2-654-25-882
D. Leszczynska
- Department of Civil Engineering, FAMU-FSU, Tallahassee, FL, USA
P. Sourivong
- US Army Center for Health Promotion and Preventive Medicine, Health Physics Program, Aberdeen Proving Ground, MD, USA
P. Babinec
- Department of Biophysics and Chemical Physics, Comenius University, Mlynska dolina F1, Bratislava 842 48, Slovakia
- Department of Chemistry, The Computational Center for Molecular Structures and Interactions, Jackson State University, Jackson, MS, USA
J. Leszczynski
- Department of Chemistry, The Computational Center for Molecular Structures and Interactions, Jackson State University, Jackson, MS, USA

Received 4 February 2003; accepted 6 October 2003.

Abstract

Basic principles of a novel method of cancer treatment are explained. Method is based on the thermal activation of an inactive prodrug encapsulated in magnetoliposomes via Neél and Brown effects of inductive heating of subdomain superparamagnetic particles to sufficiently high temperatures. This principle may be combined with targeted drug delivery (using constant magnetic field) and controlled release (using high-frequency magnetic field) of an activated drug entrapped in magnetoliposomes. Using this method drug may be applied very selectively in the particular site of organism and this procedure may be repeated several times using e.g. stealth magnetoliposomes which are circulating in a blood-stream for several days. Moreover the magnetoliposomes concentrated by external constant magnetic field in tumor vasculature may lead to embolic lesions and necrosis of a tumor body and further the heat produced for thermal activation of a drug enhances the effect of chemotherapy by local hyperthermic treatment of neoplastic cells.