Increasing longevity by decreasing sympathetic stress – early receptor blockade pharmacotherapy
Section snippets
After myocardial infarction
Long term use of β blockers following myocardial infarction reduces morbidity and mortality with most of the evidence of benefit being from the β blockers metoprolol, propanolol and timolol [10]. Mortality and sudden cardiac death are reduced by 21% and 30%, respectively, whereas the risk of reinfarction is reduced by 25% [11]. Short-term β blockade immediately after acute myocardial infarction seems unlikely to be of major benefit unless treatment is continued long term. However, estimates
Conclusion
In conclusion, initiating β receptor blocking drugs at an early age, although not too young as to effect central nervous system development, since early postnatal treatment with propanolol affects development of brain amines and behaviour [28], would likely increase longevity by their counterbalancing effects on the onslaught of the sympathetic nervous system. Newer β blocker vasodilators such as carvedilol may be more beneficial in lowering the vascular resistance and countering the increased
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