New insights into mechanism for the effect of resveratrol preconditioning against cerebral ischemic stroke: Possible role of matrix metalloprotease-9

Dong, Wenpeng; Gao, Dakuan; Lin, Hong; Zhang, Xiang; Li, Nanlin; Li, Fanfan

doi:10.1016/j.mehy.2007.04.033

« Previous Next »Medical Hypotheses
Volume 70, Issue 1 , Pages 52-55, 2008

New insights into mechanism for the effect of resveratrol preconditioning against cerebral ischemic stroke: Possible role of matrix metalloprotease-9

Wenpeng Dong
- Institute of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Chang Le West Street, No. 15, Xi’an, Shaanxi Province 710032, PR China
- These authors contributed equally.
Dakuan Gao
- Institute of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Chang Le West Street, No. 15, Xi’an, Shaanxi Province 710032, PR China
Hong Lin
- Institute of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Chang Le West Street, No. 15, Xi’an, Shaanxi Province 710032, PR China
Xiang Zhang
- Institute of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Chang Le West Street, No. 15, Xi’an, Shaanxi Province 710032, PR China
- Corresponding author. Tel.: +86 29 84775330; fax: +86 29 84775567.
Nanlin Li
- Department of Vascular and Endocrine Surgery, Xijing Hospital, Fourth Military Medical University, Chang Le West Street, No. 15, Xi’an, Shaanxi Province 710032, PR China
- These authors contributed equally.
Fanfan Li
- State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital, Fourth Military Medical University, Chang Le West Street, No. 17, Xi’an, Shaanxi 710032, PR China
- These authors contributed equally.

Received 4 April 2007; accepted 5 April 2007. published online 09 July 2007.

Summary

Resveratrol, a natural polyphenolic compound, is found in a few edible materials and is well known for its phytoestrogenic and antioxidant properties. A growing body of in vivo and in vitro evidence indicates that resveratrol has protective effect on cerebral ischemic stroke. Here, we review the effect of resveratrol on cerebral ischemic stroke, and propose a possible mechanism. During acute phases after stroke, resveratrol preconditioning suppresses matrix metalloprotease-9 activity to ameliorate blood–brain barrier disruption, edema formation and neuronal cell death caused by ischemia and reperfusion. But during delayed phases after stroke, resveratrol preconditioning conduces to cerebral angiogenesis and brain regeneration through increasing matrix metalloprotease-9 activity and expression. Resveratrol’s effect on matrix metalloprotease-9 is distinguishing in different phases because of temporal and spatial redistribution of matrix metalloprotease-9 within the cells of the neurovascular unit after cerebral ischemia. This paper also hypothesizes that resveratrol treatment after cerebral ischemia might be beneficial for cerebral angiogenesis and brain regeneration during delayed phases after stroke.