Cortistatin vaccination – A solution to growth hormone deficiency

Moaeen-ud-Din, M.; Malik, Nosheen; Guo, Yang Li; Ali, Ahmad; Babar, Masroor Ellahi

doi:10.1016/j.mehy.2009.05.020

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Volume 73, Issue 6 , Pages 1053-1054, December 2009

Cortistatin vaccination – A solution to growth hormone deficiency

M. Moaeen-ud-Din
- Functional Genomics Lab, University of Veterinary and Animal Sciences, Lahore, Pakistan
- China Education Ministry’s Key Laboratory of Animal Breeding, Genetics and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, PR China
- These authors contributed equally to this work.
- Corresponding author. Address: Functional Genomics Lab, University of Veterinary and Animal Sciences, Lahore, Pakistan. Tel.: +92 34 38702054.
Nosheen Malik
- Functional Genomics Lab, University of Veterinary and Animal Sciences, Lahore, Pakistan
- These authors contributed equally to this work.
Yang Li Guo
- China Education Ministry’s Key Laboratory of Animal Breeding, Genetics and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, PR China
Ahmad Ali
- Functional Genomics Lab, University of Veterinary and Animal Sciences, Lahore, Pakistan
Masroor Ellahi Babar
- Functional Genomics Lab, University of Veterinary and Animal Sciences, Lahore, Pakistan

Received 17 March 2009; accepted 20 May 2009. published online 29 June 2009.

Summary

Cortistatin and somatostatin are neuropeptides which have inhibitory effects on growth hormone through common five receptors. Although, both have inhibitory effects but, only cortistatin has direct inhibitory effects on growth hormone secretagogue and is more potent inhibitor of growth hormone than somatostatin. This control of growth hormone can be manipulated through immunoneutralization of cortistatin through cortistatin DNA vaccine rather than antibodies application. A DNA vaccine of cortistatin can be produced using recombinant DNA technology in a eukaryotic expression system and will serve as a tool not to only alleviate the growth hormone deficiency problems in human but, can also be used to improve growth rate in farm animals.