Maltose, a promising osmotic agent in peritoneal dialysis solution

Shu, Zhan-Jun; Peng, You-Ming; Sun, Lin; Xiao, Li; Liu, Ying-hong; Li, Jun; Ling, Guang-hui; Tang, Wen-bin; Halmurat, Upur; Liu, Fu-you

doi:10.1016/j.mehy.2010.08.007

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Volume 75, Issue 6 , Pages 645-647, December 2010

Maltose, a promising osmotic agent in peritoneal dialysis solution

Zhan-Jun Shu
- Department of Nephrology & Renal Institute, 2nd Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
- Department of Nephrology, The Fourth Affiliated Hospital of XinJiang Medical University, Huang He Road, No. 53, Urumuqi, XinJiang Autonomous Region 830000, China
You-Ming Peng
- Department of Nephrology & Renal Institute, 2nd Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
Lin Sun
- Department of Nephrology & Renal Institute, 2nd Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
Li Xiao
- Department of Nephrology & Renal Institute, 2nd Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
Ying-hong Liu
- Department of Nephrology & Renal Institute, 2nd Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
Jun Li
- Department of Nephrology & Renal Institute, 2nd Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
Guang-hui Ling
- Department of Nephrology & Renal Institute, 2nd Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
Wen-bin Tang
- Department of Nephrology & Renal Institute, 2nd Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
Upur Halmurat
- XinJiang Medical University, LiYuShan Road No. 1, Urumuqi, XinJiang Autonomous Region 830054, China
Fu-you Liu
- Department of Nephrology & Renal Institute, 2nd Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
- Corresponding author. Address: Department of Nephrology, 2nd Xiangya Hospital, Central South University, No. 139, Renmin Middle Road, Changsha, Hunan 410011, China. Tel./fax: +86 731 8529 2064.

Received 19 April 2010; accepted 1 August 2010. published online 01 September 2010.

Summary

Peritoneal dialysis has undergone considerable development from a technological point of view, and osmotic agent has played the essential role in peritoneal dialysis fluid. Because the most commonly used osmotic agent is glucose and icodextrin, there are some disadvantages related to the use of glucose-based solutions and icodextrin. So it is urgent to develop a new peritoneal dialysis osmotic agent. According to these characteristics of glucose and icodextrin, it is promising to explore a better osmotic agent of peritoneal dialysis solution which is able to allow maintenance of the maximum ultrafiltration gradient, and prevent toxicity or accumulation of unwanted substances in the blood, being non-toxic or less-toxic, furthermore the metabolite should not cause significant metabolic disturbance. Maltose may be one of promising osmotic agent and may put an important influence on development of peritoneal dialysis.