Is violence in part a lithium deficiency state?
Introduction
The discussion of violence, particularly firearm violence, has come to the forefront in the United States as a result of mass shootings in public places that have appropriately received comprehensive and widespread news coverage. This has spurred intense and passionate debate on gun control and other methods to control the apparent escalation of homicidal firearm violence [1]. In 2012, there were a total of 32,288 fatalities from firearm violence, comprising 20,666 suicides and 11,622 homicides [2]. Mass shootings in public places, although horrific, make up a very small percentage of total homicides.
Interestingly, mental illness is not the main driver of firearm homicides; however, depression is a major risk factor for firearm suicides [2]. After age 34, suicide is the leading cause of firearm death, and in the ninth decade suicide comprises approximately 95% of firearm death. Gender and racial differences are evident in firearm mortality; young black compared to white men have particularly high homicide mortality, and overall, men compared to women comprise a large majority of overall firearm fatalities [2].
Global violence has similarities to violence in the United States and suicides are the main cause of violent death [3]. Moreover, homicide vulnerability is largely seen among adolescents and young men, and the majority of violent suicide and homicide fatalities involve men.
Section snippets
Aggression and violence
Aggressive behavior is common among animals and has served a purpose to preserve life throughout evolution; it bolstered the ability to obtain food, defend against predators, and find females for reproduction [4]. In vertebrates, including humans, aggression is more pronounced among males compared to females, which is in part testosterone related [4]. In other words, male adolescents and young men, in particular, are biologically programmed to be aggressive. As such, it is not surprising that
Lithium: an important but neglected trace element
Lithium has been used for many decades to treat manic depression and only recently have its numerous mechanisms of action begun to be elucidated [9]. Lithium stimulates the production of neural stem cells and has been shown to increase amygdala and hippocampus volume and neurogenesis, and grey matter density in patients with bipolar disorders [9], [10]. Additionally, via multiple pathways, lithium inhibits the enzyme glycogen synthase kinase-3β (GSK-3β), which in turn leads to the activation of
Hypothesis
We propose the fortification of food with trace amounts of lithium and the addition of trace amounts of lithium to adolescent and adult vitamin preparations. We believe this strategy will decrease aggression, violence, suicide and homicide. Importantly, there will be no toxicity encountered.
Lithium fortification of food is worth serious consideration
As previously noted, trace amounts of lithium in drinking water compared to little or no lithium in drinking water have been associated with a significant decrease in aggression, homicide and suicide [12], [13]. It is interesting that scalp hair lithium levels reflect dietary intakes of lithium over the preceding weeks to months, and a study has shown that the scalp hair lithium content of California healthy men was threefold that of California violent offenders [24]. As mentioned, trace
Conflict of interest
None.
Acknowledgement
None.
References (27)
- et al.
Lower amygdala volume in men is associated with childhood aggression, early psychopathic traits, and future violence
Biol Psychiatry
(2014) - et al.
Antipsychotics, mood stabilisers, and risk of violent crime
Lancet
(2014) - et al.
Serum lithium as a compliance marker for food and supplement intake
Am J Clin Nutr
(2001) - et al.
The accessibility of firearms and risk for suicide and homicide victimization among household members: a systematic review and meta-analysis
Ann Intern Med
(2014) The epidemiology of firearm violence in the twenty-first century United States
Annu Rev Public Health
(2015)- et al.
Epidemiology of violent deaths in the world
Inj Prev
(2001) - et al.
Testosterone and aggressiveness
Med Sci Monit
(2005) - et al.
The neurobiology of aggression and violence
CNS Spectr
(2015) - et al.
The neurobiological bases for the development of pharmacological treatments of aggressive disorders
Curr Neuropharmacol
(2007) Testosterone and aggressive behavior in man
Int J Endocrinol Metab
(2012)
Review of lithium effects on brain and blood
Cell Transplant
Increased volume of the amygdala and hippocampus in bipolar patients treated with lithium
Neuroreport
Lithium in drinking water and the incidences of crimes, suicides, and arrests related to drug addictions
Biol Trace Elem Res
Cited by (24)
Lithium and hormesis: Enhancement of adaptive responses and biological performance via hormetic mechanisms
2023, Journal of Trace Elements in Medicine and BiologyIdentifying those at risk for COVID-19 related suicide. Response to “Hyper/neuroinflammation in COVID-19 and suicide etiopathogenesis: Hypothesis for a nefarious collision?”
2022, Neuroscience and Biobehavioral ReviewsNanoencapsulation of food bioactive constituents and its associated processes: A revisit
2022, Bioresource Technology ReportsLithium in drinking water sources in rural and urban communities in Southeastern Nigeria
2020, ChemosphereCitation Excerpt :There is growing evidence from ecological studies that lithium traces in drinking water may protect against suicide. Studies showing evidence of an inverse correlation between Li concentrations in drinking water and suicide rates (Schrauzer and Shrestha, 1990; Ohgami et al., 2009; Kapusta et al., 2011; Blüml et al., 2013; Giotakos et al., 2013; Ishii et al., 2015; Goldstein and Mascitelli, 2016) outnumber the studies that found no correlation between lithium concentrations in drinking water and suicide rates (Kabacs et al., 2011; Pompili et al., 2015), which could be related to the Li levels in the selection of their case-control samples. A recent study by Shimodera et al. (2018) investigated lithium level in tap water in relation to psychotic experiences in a general population of adolescents and reported an inverse relationship, while Ando et al. (2017) could only established an inverse association between Li level in tap water and depressive symptoms and interpersonal violence but not suicide.
Relationship between suicide mortality and lithium in drinking water: A systematic review and meta-analysis
2020, Journal of Affective DisordersCitation Excerpt :The lithium intake from other sources such as food (grains and vegetables) was not considered in the examined studies. This is while research has shown that drinking water can constitute only one-third of lithium intake in some regions (Goldstein and Mascitelli, 2016). Moreover, nearly all studies used public waterworks as the main source of drinking water supply, ignoring other sources such as bottled mineral water and wells, which usually have higher amounts of lithium (Kapusta et al., 2011; Pompili et al., 2015).
Lithium as an emerging environmental contaminant: Mobility in the soil-plant system
2018, ChemosphereCitation Excerpt :Relatively low concentrations affect the central nervous system, with reports that drinking water concentrations >0.17 mg/L reduce the incidence of suicide (Schrauzer and Shrestha, 1990) and also that concentrations >0.015 mg/L are protective against dementia (Kessing et al., 2017). Of course, Li is used in medications for bipolar disorder and manic and depressive episodes, and Goldstein and Mascitelli (2016) hypothesised that increased Li intake would reduce levels of aggression and violence. Humans may be exposed to increasing Li concentrations as it enters the environment through the use and disposal of Li-containing products.
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