Biophysical shunt theory for neuropsychopathology: pentaphasic lipid-induced model for schizophrenia

Abstract 

We propose a five-phase model for schizophrenia: (A) Imperfect diet-induced fatty acid combinations are mobilized from reservoirs during stress exposure into the bloodstream; (B) Increased brain–blood barrier permeability, with a further penetration of fat into the brain matter; (C) Rearrangement in the regional neuronal membrane fatty acids with a further physical compression of the adjacent membrane protein structures causing conformational alterations; (D) Cytokines generate further physical changes, impairing single- or multi-dispersed ion channels placed on the same neuron; (E) Ion channels are blocked, with a subsequent biophysical ion shunt-to-ion flow propagation, which results in neuronal misfiring and the appearance of schizophrenic signs and symptoms.

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