Medical Hypotheses
Volume 52, Issue 1 , Pages 77-83, January 1999

Manic–depression neural conduction speeds and action potential event dyscorrelation

7005 E 540 Road, Claremore, OK, 74017-2455, U.S.A.

Received 13 May 1997; accepted 8 September 1997.

Abstract 

In manic–depressive disorder, the monotonic, humor/receptor, excess/deficit, i.e. gain, theories have prevailed for many years, even though there is increasing evidence of a timing abnormality that may or may not be related to gain. In addition, the manic–depressive course is clearly multimodal and unpredictable except in revealing but rare cases, yet the system is real, and thus presumably deterministic, clearly suggesting a dynamic instability.

A wide range of disciplines was reviewed by the author. Those data that were significantly different by standard tests were considered. However, averaged values were always questioned.

During this review, higher water compartmentalizationdifferentialswere found in manic–depressive patients. Also indicated, event-related potential components differed in latency correlations, suggesting action potential firing eventdyscorrelation(Equation 2).

In conclusion, the manic–depressive action potential firing events may bedyscorrelatedin a space–time reference frame.

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PII: S0306-9877(97)90610-1

doi:10.1054/mehy.1997.0610

Medical Hypotheses
Volume 52, Issue 1 , Pages 77-83, January 1999