Medical Hypotheses
Volume 52, Issue 1 , Pages 85-87, January 1999

Could antioxidant therapy reduce the incidence of deafness following bacterial meningitis?

Department of Phathology, Houston Medical Center, Warner Robins, GA, 31093, U.S.A.

Received 12 June 1997; accepted 9 September 1997.

Abstract 

Sensorineural hearing loss following acute bacterial meningitis could be caused by hydroxyl radicals generated by the inflammatory response. Obstruction of cerebrospinal fluid circulation through the tela choroidae of the choroid plexuses, with subsequent rupture of the tela choroidae, would expose the auditory nerve to selective radical damage. Acute administration of lipophilic antioxidants might provide the auditory nerve with increased protection.

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PII: S0306-9877(97)90614-9

doi:10.1054/mehy.1997.0614

Medical Hypotheses
Volume 52, Issue 1 , Pages 85-87, January 1999

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