Medical Hypotheses
Volume 52, Issue 1 , Pages 53-57, January 1999

Free radical spin traps as adjuncts for the prevention and treatment of disease

  • K.M. Anderson

      Affiliations

    • Department of Medicine, Section of Medical Oncology, Rush Medical College, 1725 West Harrison Street, Chicago, IL, 60612-3842, U.S.A.
    • Department of Biochemistry, Rush Medical College, Chicago, IL, 60612-3842, U.S.A.
    • ,
  • G. Ells

      Affiliations

    • The Scotia Research Institute, Kentville, Nova Scotia, Canada
    • ,
  • P. Bonomi

      Affiliations

    • Department of Medicine, Section of Medical Oncology, Rush Medical College, 1725 West Harrison Street, Chicago, IL, 60612-3842, U.S.A.
    • ,
  • J.E. Harris

      Affiliations

    • Department of Medicine, Section of Medical Oncology, Rush Medical College, 1725 West Harrison Street, Chicago, IL, 60612-3842, U.S.A.

Received 15 May 1997; accepted 8 September 1997.

Abstract 

Free radical spin traps exhibit properties consistent with a role in the prevention or amelioration of diseases mediated by the formation of free radical species in excess of optimum constitutive requirements. At first view, it may be surprising that they have not found a place in clinical medicine. Some studies of diseases in which free radicals and oxidative stress are aberrantly over- or underabundant and which might be ameliorated by inhibiting or augmenting their formation have been reported. A number of pathophysiologic categories in which such agents have been or might be employed are briefly summarized.

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PII: S0306-9877(97)90627-7

doi:10.1054/mehy.1997.0627

Medical Hypotheses
Volume 52, Issue 1 , Pages 53-57, January 1999

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