Medical Hypotheses
Volume 52, Issue 3 , Pages 265-267, March 1999

Mechanism of induction of follicular atresia after equine chorionic gonadotrophin (eCG) antisera treatment in hypophysectomized eCG-injected hamster model: possible involvement of c-myc and cdc25

Department of Physiology, A. M. College, 102/1 Raja Rammohan Sarani, Calcutta, 700 009, India

Received 15 July 1997; accepted 8 September 1997.

Abstract 

An intracellular mechanism of induction of apoptosis of granulosa cells implicated in the initiation of experimentally induced atresia of ovarian follicle in hypophysectomized eCG-injected hamster followed by eCG-antisera treatment is proposed. Induction of atresia after withdrawal of injected eCG by eCG-antisera treatment is possibly caused by inadequate level of the gonadotropin-induced growth factor that results in apoptosis of granulosa cells associated with the activation of c-myc requiring cdc25A.

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PII: S0306-9877(97)90648-4

doi:10.1054/mehy.1997.0648

Medical Hypotheses
Volume 52, Issue 3 , Pages 265-267, March 1999

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