Medical Hypotheses
Volume 52, Issue 5 , Pages 373-376, May 1999

Abortive apoptosis as an initiator of chromosomal translocations

  • N.N. Khodarev

      Affiliations

    • Department of Radiotherapy, Loyola University Medical Center, Maywood, IL, USA
    • Department of Radiotherapy, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USAf1
    • ,
  • I.A. Sokolova

      Affiliations

    • Department of Radiotherapy, Loyola University Medical Center, Maywood, IL, USA
    • ,
  • A.T.M. Vaughan

      Affiliations

    • Department of Radiotherapy, Loyola University Medical Center, Maywood, IL, USA

Received 17 November 1997; accepted 23 December 1997.

Abstract 

Apoptosis is a well-recognized regulator of a cell populations size and structure. Irreversible stages of apoptosis lead to activation of different enzymatic cascades, changes in cell morphology and DNA fragmentation. However, little is known about nuclear events which accompany the initial stages of apoptosis. These events are connected with introduction of limited amounts of double strand breaks into genomic DNA, some of which may be subsequently rejoined. We hypothesize here that the initial stages of apoptotic DNA fragmentation may be reversible and connected with the initiation of recombinational events and certain chromosomal translocations. The factors influencing apoptosis reversibility and cell survival after delivery of apoptotic stimuli may provide new insights into mechanisms of lymphocyte development and tumorigenesis.

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  • f1 nkhodar@luc.edu

PII: S0306-9877(97)90672-1

doi:10.1054/mehy.1997.0672

Medical Hypotheses
Volume 52, Issue 5 , Pages 373-376, May 1999

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