Medical Hypotheses
Volume 52, Issue 1 , Pages 1-8, January 1999

The key role of histamine in the development of atherosclerosis and coronary heart disease

Tulane University School of Medicine, New Orleans, LA, 70125, U.S.A.

Received 15 August 1997; accepted 25 August 1998.

Abstract 

Vitamin C-deficiency is known to cause a disturbance of cholesterol metabolism. Suboptimal plasma ascorbic acid levels also cause increased blood histamine levels, which are exaggerated by sleep-lack and other forms of stress. Histaminemia causes separation of vascular endothelial cells. It is here suggested that the histaminemia of stress and ascorbate depletion combine to cause damage to the arterial endothelium and predispose to atherosclerosis, the principal cause of myocardial infarction.

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PII: S0306-9877(97)90775-1

doi:10.1054/mehy.1997.0775

Medical Hypotheses
Volume 52, Issue 1 , Pages 1-8, January 1999

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