Medical Hypotheses
Volume 51, Issue 4 , Pages 305-307, October 1998

A re-evaluation of the mechanism of action of botulinum toxin on facial movement disorders in man

  • F.E. Leon-S

      Affiliations

    • Corresponding Author InformationCorrespondence to: Dr Fidias E. Leon-S, MD, PhD, Dirección: Conjunto Residencial Villa de los Conquistadores, casa 49, Bucaramanga, Colombia, South America. (Phone: 57 76 334508, Fax: +57 76 524958)
    • ,
  • K. Arimura

      Affiliations

    • Third Department of Internal Medicine, Kagoshima University School of Medicine, Kagoshima, Japan
    • Unit of Clinical Neurology and Laboratory of Clinical Neurophysiology, Department of Basic Sciences, UIS-Santander University School of Medicine, Bucaramanga, Colombia, South America USA
    • ,
  • A.M. Chavez

      Affiliations

    • Section of Physiology, Department of Basic Sciences, Bucaramanga, Colombia, South America USA
    • Unit of Clinical Neurology and Laboratory of Clinical Neurophysiology, Department of Basic Sciences, UIS-Santander University School of Medicine, Bucaramanga, Colombia, South America USA

Received 27 March 1997; accepted 14 May 1997.

Abstract 

Despite a lot of research aimed at clarifying the mechanism of action of botulinum toxin, mostly at supraspinal levels, a complete understanding of it is still elusive. However, recent investigations, including our own, allow us to suggest that, in facial muscles, the effects of botulinum toxin are not only in the neuromuscular junctions affecting the acetylcholine release but also modify the sensory inflow with subsequent changes on the muscle spindle-gammamotoneuron system.

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PII: S0306-9877(98)90053-6

Medical Hypotheses
Volume 51, Issue 4 , Pages 305-307, October 1998

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