Medical Hypotheses
Volume 51, Issue 6 , Pages 485-488, December 1998

Segmental duplications of somatic (human) chromatids

USC Medical School, 2011 Zonal Avenue, Los Angeles, CA 90033, USA

Received 12 June 1997; accepted 9 August 1997.

Abstract 

The paper discusses a mechanism for short-long duplications of segments of somatic chromatids in cancer cells. Based on the Frenkel-Kontorova model, the mechanism accounts for the high incidence of duplications on the long arm of almost all chromatids.

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PII: S0306-9877(98)90069-X

Medical Hypotheses
Volume 51, Issue 6 , Pages 485-488, December 1998