Medical Hypotheses
Volume 52, Issue 3 , Pages 235-238, March 1999

Does maximizing programmed cell death necessarily yield an optimum clinical advantage?

  • D. OU

      Affiliations

    • Department of Pathology, University of Illinois Medical School at Chicago and the West Side V.A. Hospital, Chicago, U.S.A.
    • ,
  • K.M. Anderson

      Affiliations

    • Department of Medicine, Rush Medical College, Chicago, IL, 60612, U.S.A.
    • Department of Biochemistry, Rush Medical College, Chicago, IL, 60612, U.S.A.
    • ,
  • W. Leslie

      Affiliations

    • Department of Medicine, Rush Medical College, Chicago, IL, 60612, U.S.A.
    • ,
  • P. Bonomi

      Affiliations

    • Department of Medicine, Rush Medical College, Chicago, IL, 60612, U.S.A.
    • ,
  • J.E. Harris

      Affiliations

    • Department of Medicine, Rush Medical College, Chicago, IL, 60612, U.S.A.
    • Department of Immunology, Rush Medical College, Chicago, IL, 60612, U.S.A.

Received 3 July 1998; accepted 2 December 1998.

Abstract 

Generally it has been believed that a maximum therapeutic induction of programmed cell death in cancer cells is universally desirable. As a corollary, the presence of Bcl-2, a major anti-programmed cell death protein, is considered an unfavorable prognostic sign. The latter is not and the former may not be universally true.

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PII: S0306-9877(98)90839-8

doi:10.1054/mehy.1998.0839

Medical Hypotheses
Volume 52, Issue 3 , Pages 235-238, March 1999

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