Medical Hypotheses
Volume 54, Issue 2 , Pages 157-166, February 2000

Schizophrenia: a purinergic hypothesis

Departamento de Bioquı́mica – ICBS – Universidade Federal do Rio, Grande do Sul, Porto Alegre – RS –CEP, 90035–003, Brazil

Received 21 December 1998; accepted 6 January 1999.

Abstract 

Knowledge of the physiological roles of the purinergic system and its influence on other neurotransmitter systems has greatly advanced. In this article, a purinergic model is proposed as an attempt to integrate several findings in schizophrenia. According to this hypothesis, a purinergic system dysfunction would mainly result in reduced adenosinergic activity. This model also addresses the systemic aspects of schizophrenia, based on peripheral roles of purines, such as modulation of the immune system.

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PII: S0306-9877(99)90003-8

doi:10.1054/mehy.1999.0003

Medical Hypotheses
Volume 54, Issue 2 , Pages 157-166, February 2000

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