Medical Hypotheses
Volume 54, Issue 2 , Pages 172-176, February 2000

An interesting observation of the position of some electronegative atoms in the taxol molecule

Department of Pharmacology, Toxicology & Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas, USA

Received 25 September 1998; accepted 9 December 1998.

Abstract 

A study of the absolute energy-minimized configuration of the taxol molecule revealed that many oxygen atoms in this molecule and a nitrogen atom on the side chain are located on the same plane. A comparison of these electronegative atoms with information provided from existing literature indicated that most of these noted atoms conform with the reported structureÐactivity relationship (cytotoxicity, antineoplastic activity, tubulin assembly property, etc.). This observation may assist investigators in their future design of simpler, possibly clinically efficacious molecules related to taxol.

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PII: S0306-9877(99)90010-5

doi:10.1054/mehy.1999.0010

Medical Hypotheses
Volume 54, Issue 2 , Pages 172-176, February 2000

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