Medical Hypotheses
Volume 54, Issue 2 , Pages 180-181, February 2000

Gene transfer-mediated intracellular photodynamic therapy

  • M. Babincová

      Affiliations

    • Department of Biophysics and Chemical Physics, Comenius University, Bratislava, Slovakia
    • ,
  • P. Sourivong

      Affiliations

    • Physics Department, University of North Dakota, Grand Fork, ND, USA
    • ,
  • P. Babinec

      Affiliations

    • Department of Chemistry, Jackson State University, Jackson, MS, USA

Received 18 August 1998; accepted 8 December 1998.

Abstract 

The main limitation of photodynamic therapy is a very short penetrance length of the light in tissues. To overcome this shortcoming, a new method is proposed, where first a gene encoding protein luciferase is delivered using, e.g. adenovirus vector to the neoplastic cells and, after its expression, the photosensitizer, which should be activated, together with luciferin are injected to the organism. After their accumulation in the cancer cells, the photosensitizer activation is accomplished via light produced by chemiluminiscent reaction of luciferase and luciferin.

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PII: S0306-9877(99)90012-9

doi:10.1054/mehy.1999.0012

Medical Hypotheses
Volume 54, Issue 2 , Pages 180-181, February 2000

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