Elsevier

Medical Hypotheses

Volume 53, Issue 6, December 1999, Pages 488-489
Medical Hypotheses

Regular Article
Prevention of progression in chronic myeloid leukemia by altering DNA methylation with a pyridoxine analogue

https://doi.org/10.1054/mehy.1999.0796Get rights and content

Abstract

Altered DNA methylation is one mechanism by which progression might occur in tumors. Progression in chronic myeloid leukemia (CML) was initially thought to be due to mutations. However, altered DNA methylation might be responsible for the same. An agent whose probable target is DNA methylation has been shown to improve hematopoiesis in CML. Pyridoxine is involved in methylation reactions. At present, the link between dietary factors like pyridoxine and cancer is somewhat tenuous. It is hypothesized that a suitable pyridoxine analogue might, by blocking DNA methylation, prevent progression in CML.

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