Regular ArticleModern diets and diseases: NO–zinc balance
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Zink, auto-immuunziekten, voedselallergieën en kanker. ‘Zinc, autoimmune diseases, food allergies and cancer’
Overgewicht, hoge bloeddruk, diabetes mellitus, hart- en vaatziekten...een tekort aan spoor-elementen. ‘Obesity, hypertension, diabetes mellitus, atherosclerosis... a trace element-deficiency.’
Moderne voeding, milieu, virussen en kanker. (I) ‘Modern nutrition, environment, viruses and cancer. (I)’
ORTHO
Moderne voeding, milieu, virussen en kanker. (II) ‘Modern nutrition, environment, viruses and cancer. (II)‘
ORTHO
Zinkarm lichaam kan worden gezien als ‘broedstoof’ voor ziekteverwekkers. *lsquos;Zinc-deficient bodies can be seen as ‘hotbeds’ for disease agents.’
Arts en alternatief
Zinkdeficiëntie predisponeert tot wel of niet virusgeı̈nduceerde (auto-)immuunziekten zoals AIDS en kanker. ‘Zinc deficiency predisposes to (auto)immune diseases, whether or not virus-induced, such as AIDS and cancer.’
Tijdschrift Integrale Geneeskunde
Active human immunodeficiency virus protease is required for viral infectivity
Proc Natl Acad Sci USA
Regulation of HIV-1 protease activity through cysteine modification
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Recent excitement regarding metallothionein
Proc Natl Acad Sci USA
Thiolate ligands in metallothionein confer redox activity on zinc clusters
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The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase
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Control of zinc transfer between thionein, metallothionein, and zinc proteins
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The ATP-metallothionein complex
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Zinc inhibition of renin and the protease from human immunodeficiency virus type 1
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Copper inhibits the protease from human immunodeficiency virus 1 by both cyteine-dependent and cysteine-independent mechanisms
Proc Natl Acad Sci USA
Intracellular glutathione levels in T cell subsets decrease in HIV-infected individuals
AIDS Res Hum Retrovir
Glutathione depletion in HIV-infected patients: role of cysteine deficiency and effect of oral N-acetylcysteine
AIDS
Cited by (54)
Effect of selenium antagonist lead-induced damage on Th1/Th2 imbalance in the peripheral blood lymphocytes of chickens
2019, Ecotoxicology and Environmental SafetyCitation Excerpt :It is reported that the decrease of selenoprotein expression caused by Se deficiency results in a Th1/Th2 balance disorder in chicken dendritic cells (Sun et al., 2018). Research shows that the modern Western diet has a large number of refined products that lack Se, which can lead to a Th1/Th2 imbalance, causing chronic infections, allergies and autoimmunity (Sprietsma, 1999). Se supplement alleviated Pb-caused oxidative damage by up-regulating the expression of selenoproteins in neutrophils in chickens (Sprietsma, 1999).
Imaging free zinc levels in vivo - What can be learned?
2012, Inorganica Chimica ActaCitation Excerpt :The tight binding sites for Zn(II) (log K > 11) involve the first four thiol groups in cysteines of the MTs while moderate binders (log K between 9 and 11) and loose binding have log K values ∼7.7 [21,22,25–28]. These forms are known to participate in a wide variety of redox reactions and Zn(II) transport in cells and specific organelles through reactions with other known redox active species such as glutathione [24] and NO [29]. As changes in the amount of free unbound Zn(II) is known to trigger a multitude of genes, dysfunctions involving MTs in mammals are thought to ultimately pave the way for greater oxidative stress and possibly cancer [30], a better understanding of both how much and which forms of zinc are involved in vivo are warranted.
Geoepidemiology of COPD and idiopathic pulmonary fibrosis
2010, Journal of AutoimmunityRole of zinc and zinc transporters in the molecular pathogenesis of diabetes mellitus
2005, Medical HypothesesMineral micronutrients in asthma
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