Regular ArticleResistance of cancer cells to immune recognition and killing
References (49)
Hydrophobic interactions in plasma proteins and pathogenesis of atherosclerosis
Atherosclerosis
(1995)- et al.
Plasma macromolecular protein complex: interaction with fibrin and fibrinolysis
Thromb Res
(1995) Aurin tricarboxylic acid inhibits fibrinogen clotting by forming soluble fibrin complexes
Thromb Res
(1995)- et al.
Plasminogen activators, tissue degeneration and cancer
Adv Cancer Res
(1985) - et al.
Significance of fibrin formation and dissolution in the pathogenesis and treatment of cancer
Med Hypotheses
(1991) - et al.
Increased vascular permeability: a major cause of hypoalbuminemia in disease and injury
Lancet
(1985) New strategies for enhancing the immunogenicity of tumors
Curr Opinion Immunol
(1993)Viruses in the treatment of cancer
Lancet
(1971)Estimating the Prevalence of Cancer in the United States
Cancer
(1997)Tumor antigens known to be immunogen in man. Specific immunotherapy of cancer with vaccines
Ann N Y Acad Sci
(1993)
Depressed immune surveillance against cancer: role of deficient T cell: extracellular matrix interactions
Cell Adhes Communic
The possible mechanism of benefit effects of the mature thymic calf extracts (THYMEX-L) in mice bearing a transplanted melanoma
Interntl J Thymology
Possible mechanism of success and allotransplantation in nature: mammalian pregnancy
Med Hypotheses
Fibrinolysis versus fibrinogenolysis of man: resistance of fibrinogen to breakdown by fibrinolytic activity induced by venous occlusion
Experientia
Immunoglobulin G and serum albumin isolated from the articular cartilage of patients with rheumatoid arthritis contains covalent heteropolymers with proteoglycans
Rheumatol Int
In vitro preparation and partial characterization of a novel complex of human fibrinogen with albumin
J Protein Chem
Bioelectric theory of pathogenesis of atherosclerosis
J Bioelectricity
Effect of thiol-induced disulfide exchange on plasma clotting and fibrinolysis
Thromb Haemost
Suramin inhibits thrombin induced fibrinogen clotting by forming soluble fibrin complexes
Thromb Haemost
Comments on plasma fibrinogen levels by functional methods
Thromb Haemost
Fibrin as a component of the tumor stroma: origins and biological significance
Cancer Metastasis Rev
Fibrin deposition in primary and metastatic human brain tumors
Blood Coagul Fibrinolysis
Fibrinogen–fibrin transformation in situ in renal cell carcinoma
Anticancer Res
Cancer procoagulant: a factor X activating procoagulant from malignant tissue
Thromb Res
Cited by (13)
Networks that stop the flow: A fresh look at fibrin and neutrophil extracellular traps
2019, Thrombosis ResearchCitation Excerpt :These include their own surfaces [153] as well as secreted molecules (such as staphylocoagulase [154]) that induce fibrin polymerization, and proteins that bind fibrin (e.g. protein M [155]). Interestingly, this versatility of approaches are not only seen with external parasites, but also with internal ones: tumor cells have been suggested to use fibrin formation to their advantage possibly by similarly shielding themselves from immune recognition [156], or, in certain cases, inducing fibrinolysis which is thought to help tumor dissemination and metastasis [157]. Citrullination, the conversion of peptidyl-arginyl residues to peptidyl-citrulline via deimination has been in the center of attention in the field of rheumatoid arthritis for a long time (reviewed in [158]), and PAD enzymes responsible for this irreversible post-translational modification have been extensively investigated.
Pathophysiological significance of protein hydrophobic interactions: An emerging hypothesis
2018, Medical HypothesesCitation Excerpt :These findings indicate that the immune therapy is directed not so much at stimulating the immune system of a host, but at improving the surveillance capability of the cellular defense system. The proposed mechanism of this type of therapy is based on a strong interaction between the hydrophobic regions of fibrin–albumin coat on tumor cells and the apolar side chains of a superantigen [50]. As a result, such sandwiched cells become 'non-self ' and are subsequently recognized and attacked by natural killer (NK) cells.
Differential regulation of macrophage inflammatory activation by fibrin and fibrinogen
2017, Acta BiomaterialiaCitation Excerpt :In cancer, fibrinogen is thought to play a role in metastasis, since lack of fibrinogen has been shown to diminish tumor metastasis [62,63]. Fibrin is found within tumor tissues [64] and may prevent macrophage inflammatory activation to promote tumor survival. In cardiovascular disease, increased plasma levels of fibrinogen and fibrin degradation products are associated with disease progression [65–68], and these molecules, in addition to fibrin, are found within atherosclerotic lesions but not in normal healthy vessels [69].
The prothrombotic activity of cancer cells in the circulation
2016, Blood ReviewsCitation Excerpt :Perhaps TF expression confers a survival advantage to cancer cells in the circulation. Indeed, inhibition of TF, FXa or thrombin has been shown to prevent the formation of metastatic niches in SCID mice bearing human melanoma tumors [41–43]. Similarly, C57Bl/6 mice injected with highly metastatic tumor cells devoid of TF were protected from metastatic disease [44].
Bromelain's activity and potential as an anti-cancer agent: Current evidence and perspectives
2010, Cancer LettersCitation Excerpt :Additionally, tumor cells are believed to form a protective coat by polymerizing fibrin and human serum albumin. This coat is resistant to the proteolytic activity of internal proteases such as plasmin and provides tumor cells with protection against the immune system [73]. A recent study of the thrombin receptor expression in primary tumor cells [74] can provide an insight into the molecular mechanisms of such coat formation.
Rationale for the treatment of cancer with sodium selenite
2005, Medical Hypotheses