Medical Hypotheses
Volume 55, Issue 1 , Pages 1-4, July 2000

Parvovirus-mediated antineoplastic activity exploits genome instability

  • F.F. Shadan

      Affiliations

    • Scripps Clinic and Research Foundation, La Jolla, California, USA
    • ,
  • L.P. Villarreal

      Affiliations

    • Department of Molecular Biology and Biochemistry, University of Irvine, California, USA

Received 22 October 1998; accepted 13 April 1999.

Abstract 

The generation and accumulation of genetic mutations have been associated with carcinogenesis. Epidemiological and experimental evidence implicate parvoviruses in growth inhibition (oncosuppression) and selective destruction (oncolysis) of tumor cells. It is proposed here that parvoviruses can preferentially target genetically unstable tumor cells, which are deficient in DNA repair mechanisms. This selective strategy may serve as a virus-based therapeutic approach against cancer.

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PII: S0306-9877(99)90887-3

doi:10.1054/mehy.1999.0887

Medical Hypotheses
Volume 55, Issue 1 , Pages 1-4, July 2000

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