Medical Hypotheses
Volume 55, Issue 5 , Pages 454-455, November 2000

Insulin secretion as a potential determinant of homocysteine levels

Pantox Laboratories, San Diego, USA

Received 17 March 1999; accepted 19 July 1999.

Abstract 

The recently reported association between insulin resistance and elevated plasma homocyst(e)ine may reflect the fact that hyperinsulinemia suppresses hepatocyte expression of cystathionine beta-synthase, as demonstrated in rats. Thus, other measures which enhance diurnal insulin secretion – such as a high-glycemic-index diet – can be expected to increase homocysteine levels.

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PII: S0306-9877(99)91008-3

doi:10.1054/mehy.1999.1008

Medical Hypotheses
Volume 55, Issue 5 , Pages 454-455, November 2000

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