Medical Hypotheses
Volume 55, Issue 2 , Pages 103-108, August 2000

Is cancer an autoimmune process dependent on anti-apoptotic autoantibodies?

  • Y. Bar-Dayan

      Affiliations

    • Department of Medicine B and Research Unit of Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer Hospital and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
    • ,
  • S.V. Kaveri

      Affiliations

    • INSERM U430 and Université Pierre et Marie Curie, Hôpital Broussais, Paris, France
    • ,
  • M.D. Kazatchkine

      Affiliations

    • INSERM U430 and Université Pierre et Marie Curie, Hôpital Broussais, Paris, France
    • ,
  • Y. Shoenfeld

      Affiliations

    • Department of Medicine B and Research Unit of Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer Hospital and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

Received 14 June 1999; accepted 18 October 1999.

Abstract 

Dysregulated apoptosis is a potentially important mechanism in the pathogenesis of cancer. Autoantibodies, which inhibit apoptosis, have recently been identified in patients with malignant diseases. We suggest that such inhibitory autoantibodies participate in tumorigenesis. These views may provide a basis for the increased incidence of cancer in patients with autoimmune diseases and have novel therapeutic implications for cancer.

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PII: S0306-9877(99)91035-6

doi:10.1054/mehy.1999.1035

Medical Hypotheses
Volume 55, Issue 2 , Pages 103-108, August 2000

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