Regular ArticleThe ketogenic diet may have mood-stabilizing properties
References (42)
- et al.
The ketogenic diet: a practical guide for caregivers
J Am Diet Assoc
(1998) - et al.
Ketogenic diet in the treatment of refractory epilepsy in childhood
Pediatr Neurol
(1999) Clinical efficacy of the ketogenic diet
Epilepsy Res
(1999)- et al.
Nephrolithiasis associated with the ketogenic diet
J Urol
(2000) - et al.
Development and evaluation of a ketogenic diet program
J Am Diet Assoc
(1999) - et al.
Identification of cerebral acetone by 1H-MRS in patients with epilepsy controlled by ketogenic diet
MAGMA
(1999) - et al.
Vagus nerve stimulation: a new tool for brain research and therapy
Biol Psychiatry
(2000) - et al.
Frontal cortex and basal ganglia metabolic rates assessed by positron emission tomography with [18F]2-deoxyglucose in affective illness
J Affect Disord
(1986) Ketogenic diet in the treatment of epilepsy
N Engl J Med
(1928)- et al.
Higher ketogenic diet ratios confer protection from seizures without neurotoxicity
Epilepsy Res
(2000)
The ketogenic diet for intractable epilepsy in adults: preliminary results
Epilepsia
Complications of the ketogenic diet
Epilepsia
Cardiac complications in pediatric patients on the ketogenic diet
Neurology
An interdisciplinary team approach to implementing the ketogenic diet for the treatment of seizures
Pediatr Nurs
The efficacy of the ketogenic diet – 1998: a prospective evaluation of intervention in 150 children
Pediatrics
A multicenter study of the efficacy of the ketogenic diet
Arch Neurol
The ketogenic diet in refractory epilepsy: the experience of Children's Hospital of Pittsburgh
Clin Pediatr Philadelphia
Medication cost reduction in children on the ketogenic diet: data from a prospective study
J Child Neurol
Carbamazepine in manic-depressive illness: a new treatment
Am J Psychiatry
Carbamazepine versus lithium in mania: a double-blind study
J Clin Psychiatry
Valproate in the treatment of acute mania: a placebo-controlled study
Arch Gen Psychiatry
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The role of ketogenic therapy in developmental disorders
2023, Journal of Psychiatric ResearchInfluence of anti-obesity strategies on brain function in health and review: A review
2023, Neurochemistry InternationalKetogenic diet as a metabolic therapy for bipolar disorder: Clinical developments
2023, Journal of Affective Disorders ReportsCitation Excerpt :The ketogenic diet has been used as an effective intervention for epilepsy since the 1920s (Neal et al., 2008). Recently, it has garnered more interest on its potential therapeutic effects on neuropsychiatric disorders and BD (Dsouza et al., 2019; El-Mallakh and Paskitti, 2001). The nutritional plan use fats as its main energy substrates replacing glucose by reducing carbohydrate intake.
Changes in tryptophan and kynurenine pathway metabolites in the blood of children treated with ketogenic diet for refractory epilepsy
2019, SeizureCitation Excerpt :The same mechanism of KD-induced KAT upregulation cannot be ruled out as a driver of the anticonvulsant effect in our patients. It has also been documented that the KD exerts antidepressant and mood-stabilizing properties [20,21]. Similarly, Lee and coworkers suggested that mice fed a high-fat diet who perform aerobic exercise exhibit a rising KYNA/3-OH-KYN ratio, which is believed to be a meaningful anti-aging indicator [22].
The influence of ketogenic diets on mood stability in bipolar disorder
2019, Asian Journal of PsychiatryDietary interventions for autism spectrum disorder: New perspectives from the gut-brain axis
2018, Physiology and BehaviorCitation Excerpt :A systematic review of the administration of KD to individuals with ASD note positive effects especially for mild and moderate cases and some reports of improvements in seizure symptoms and behavioral deficits [9]. Yet, KD is also reported to lead to adverse effects including constipation, elevated serum cholesterol, decreased serum protein, hemolytic anemia, menstrual irregularities, and hospitalization due to vomiting and dehydration [5, 23]. So, it is important to understand the physiological effects of KD diets before recommending its use in ASD or other disorders.
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Correspondence to: Rif S. El-Mallakah MD, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA